Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings

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Martin, Cederlöf,1980-Karolinska Institutet (author)

Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings

Article/chapterEnglish2016

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2016-07-04
London, United Kingdom :BioMed Central,2016
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LIBRIS-ID:oai:DiVA.org:oru-51459
ISSN:1471-244X
10616/45556hdl
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51459URI
https://doi.org/10.1186/s12888-016-0922-6DOI
http://hdl.handle.net/10616/45556URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:133855559URI

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Language:English
Summary in:English

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Funding Agencies:Swedish Celiac SocietySwedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM) framework 340-2013-5867
Background: To assess the risk of psychiatric disorders in Ehlers-Danlos syndrome (EDS) and hypermobility syndrome.Methods: Nationwide population-based matched cohort study. EDS, hypermobility syndrome and psychiatric disorders were identified through Swedish national registries. Individuals with EDS (n = 1,771) were matched with comparison individuals (n = 17,710). Further, siblings to individuals with EDS who did not have an EDS diagnosis themselves were compared with matched comparison siblings. Using conditional logistic regression, risk of autism spectrum disorder (ASD), bipolar disorder, attention deficit hyperactivity disorder (ADHD), depression, attempted suicide, suicide and schizophrenia were estimated. The same analyses were conducted in individuals with hypermobility syndrome (n = 10,019) and their siblings.Results: EDS was associated with ASD: risk ratio (RR) 7.4, 95 % confidence interval (95 % CI) 5.2-10.7; bipolar disorder: RR 2.7, CI 1.5-4.7; ADHD: RR 5.6, CI 4.2-7.4; depression: RR 3.4, 95 % CI 2.9-4.1; and attempted suicide: RR 2.1, 95 % CI 1.7-2.7, but not with suicide or schizophrenia. EDS siblings were at increased risk of ADHD: RR 2.1, 95 % CI 1.4-3.3; depression: RR 1.5, 95 % CI 1.1-1.8; and suicide attempt: RR 1.8, 95 % CI 1.4-2.3. Similar results were observed for individuals with hypermobility syndrome and their siblings.Conclusions: Individuals with EDS and hypermobility syndrome are at increased risks of being diagnosed with psychiatric disorders. These risk increases may have a genetic and/or early environmental background as suggested by evidence showing that siblings to patients have elevated risks of certain psychiatric disorders.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
Cohort study
Ehlers-Danlos syndrome
Hypermobility syndrome
Epidemiology
Psychiatric disorders
Psychiatry
Psykiatri

Added entries (persons, corporate bodies, meetings, titles ...)

Larsson, Henrik,1975-Karolinska Institutet(Swepub:oru)hiln (author)
Lichtenstein, PaulKarolinska Institutet (author)
Almqvist, CatarinaKarolinska Institutet (author)
Serlachius, EvaKarolinska Institutet (author)
Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, United States(Swepub:oru)jsln (author)
Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Karolinska Institutet
Karolinska Institutet

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In:BMC PsychiatryLondon, United Kingdom : BioMed Central161471-244X

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