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Electroactive biomi...
Electroactive biomimetic collagen-silver nanowire composite scaffolds
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- Wickham, Abeni (author)
- Linköpings universitet,Molekylär fysik,Tekniska fakulteten
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- Vagin, Mikhail (author)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten
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- Khalaf, Hazem, 1981- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Cardiovascular Research Centre, Örebro University Hospital, Örebro, Sweden,University of Örebro, Sweden
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- Bertazzo, Sergio (author)
- Department of Medical Physics and Biomedical Engineering, University College London, London, UK,UCL, England
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- Hodder, Peter (author)
- TA Instruments Ltd., Elstree, UK,TA Instruments Ltd, England
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- Dånmark, Staffan (author)
- Linköpings universitet,Molekylär fysik,Tekniska fakulteten
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- Bengtsson, Torbjörn, 1955- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Cardiovascular Research Centre,University of Örebro, Sweden
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- Altimiras, Jordi (author)
- Linköpings universitet,Biologi,Tekniska fakulteten
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- Aili, Daniel (author)
- Linköpings universitet,Molekylär fysik,Tekniska fakulteten
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(creator_code:org_t)
- 2016
- 2016
- English.
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In: Nanoscale. - Cambridge : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 8:29, s. 14146-14155
- Related links:
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http://discovery.ucl...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Electroactive biomaterials are widely explored as bioelectrodes and as scaffolds for neural and cardiac regeneration. Most electrodes and conductive scaffolds for tissue regeneration are based on synthetic materials that have limited biocompatibility and often display large discrepancies in mechanical properties with the surrounding tissue causing problems during tissue integration and regeneration. This work shows the development of a biomimetic nanocomposite material prepared from self-assembled collagen fibrils and silver nanowires (AgNW). Despite consisting of mostly type I collagen fibrils, the homogeneously embedded AgNWs provide these materials with a charge storage capacity of about 2.3 mC cm(-2) and a charge injection capacity of 0.3 mC cm(-2), which is on par with bioelectrodes used in the clinic. The mechanical properties of the materials are similar to soft tissues with a dynamic elastic modulus within the lower kPa range. The nanocomposites also support proliferation of embryonic cardiomyocytes while inhibiting the growth of both Gram-negative Escherichia coli and Gram-positive Staphylococcus epidermidis. The developed collagen/AgNW composites thus represent a highly attractive bioelectrode and scaffold material for a wide range of biomedical applications.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nanoscale
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To the university's database
- By the author/editor
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Wickham, Abeni
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Vagin, Mikhail
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Khalaf, Hazem, 1 ...
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Bertazzo, Sergio
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Hodder, Peter
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Dånmark, Staffan
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Bengtsson, Torbj ...
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Altimiras, Jordi
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Aili, Daniel
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
- Articles in the publication
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Nanoscale
- By the university
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Örebro University
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Linköping University