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Decreased survival ...
Decreased survival in pancreatic cancer patients with high concentrations of organochlorines in adipose tissue
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- Hardell, Lennart, 1944- (author)
- Örebro universitet,Institutionen för naturvetenskap
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Carlberg, Michael (author)
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- Hardell, Karin, 1975- (author)
- Örebro universitet,Institutionen för naturvetenskap
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- Björnfoth, Helen, 1966- (author)
- Örebro universitet,Akademin för naturvetenskap och teknik,MTM
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Wickbom, Gunnar (author)
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Ionescu, Mircea (author)
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap,MTM
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- Lindström, Gunilla, 1949- (author)
- Örebro universitet,Institutionen för naturvetenskap,MTM
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Biomedicine and Pharmacotherapy. - : Elsevier BV. - 0753-3322 .- 1950-6007. ; 61:10, s. 659-664
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We analysed adipose tissue concentrations of persistent organic pollutants (POPs) in 21 cases with exocrine pancreatic cancer. The comparison group consisted of 59 subjects. Significantly increased concentrations of polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), sum of chlordanes and polybrominated diphenylethers (PBDEs) were found in the cases. For 1,1,-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) no significant difference was seen. For PCBs no odds ratio (OR) could be calculated since all cases had concentration>median in controls used as a cut-off. HCB yielded OR=53.0, 95% confidence interval (CI)=4.64-605 and sum of chlordanes OR=18.4, 95% CI=2.71-124 whereas OR was not significantly increased for p,p'-DDE or PBDEs. Body mass index (BMI) at the time of tissue sampling was significantly lower for the cases. This might have influenced the results. Using BMI one year previously or decreasing the concentrations of POPs with the same percentage as weight loss among the cases did not change the results. Survival of the cases was shorter in the group with the concentration of POPs>median among cases, significantly so for the sum of PCBs (147 vs. 294 days), p,p'-DDE (134 vs. 302 days), and sum of chlordanes (142 vs. 294 days) in the high and low group, respectively. The results were based on a low number of cases and should be interpreted with caution.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- NATURAL SCIENCES
- NATURVETENSKAP
- MEDICINE
- MEDICIN
- Chemistry
- Kemi
- Chemistry
- Kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hardell, Lennart ...
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Carlberg, Michae ...
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Hardell, Karin, ...
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Björnfoth, Helen ...
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Wickbom, Gunnar
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Ionescu, Mircea
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show more...
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van Bavel, Bert, ...
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Lindström, Gunil ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Biomedicine and ...
- By the university
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Örebro University