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Enantioselective An...
Enantioselective Analytical- and Preparative-Scale Separation of Hexabromocyclododecane Stereoisomers Using Packed Column Supercritical Fluid Chromatography
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- Riddell, Nicole, 1979- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Wellington Laboratories Inc., Guelph, Canada,Man-Technology-Environment (MTM) Research Center
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- Mullin, Lauren Gayle, 1984- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Waters Corporation, Milford, USA,Man-Technology-Environment (MTM) Research Center
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Norwegian Institute for Water Research, Oslo, Norway,Man-Technology-Environment (MTM) Research Center
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- Ericson Jogsten, Ingrid, 1980- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM) Research Center
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- McAlees, Alan (author)
- Wellington Laboratories Inc., Guelph, Canada
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- Brazeau, Allison (author)
- Wellington Laboratories Inc., Guelph, Canada
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- Synnott, Scott (author)
- Wellington Laboratories Inc., Guelph, Canada
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- Lough, Alan (author)
- Department of Chemistry, University of Toronto, Toronto, Canada
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- McCrindle, Robert (author)
- Wellington Laboratories Inc., Guelph, Canada; Chemistry Department, University of Guelph, Guelph, Canada
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- Chittim, Brock (author)
- Wellington Laboratories Inc., Guelph, Canada
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(creator_code:org_t)
- 2016-11-10
- 2016
- English.
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In: Molecules. - Basel, Switzerland : MDPI AG. - 1431-5157 .- 1420-3049. ; 21:11
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Abstract
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- Hexabromocyclododecane (HBCDD) is an additive brominated flame retardant which has been listed in Annex A of the Stockholm Convention for elimination of production and use. It has been reported to persist in the environment and has the potential for enantiomer-specific degradation, accumulation, or both, making enantioselective analyses increasingly important. The six main stereoisomers of technical HBCDD (i.e., the (+) and (-) enantiomers of α-, β-, and γ-HBCDD) were separated and isolated for the first time using enantioselective packed column supercritical fluid chromatography (pSFC) separation methods on a preparative scale. Characterization was completed using published chiral liquid chromatography (LC) methods and elution profiles, as well as X-ray crystallography, and the isolated fractions were definitively identified. Additionally, the resolution of the enantiomers, along with two minor components of the technical product (δ- and ε-HBCDD), was investigated on an analytical scale using both LC and pSFC separation techniques, and changes in elution order were highlighted. Baseline separation of all HBCDD enantiomers was achieved by pSFC on an analytical scale using a cellulose-based column. The described method emphasizes the potential associated with pSFC as a green method of isolating and analyzing environmental contaminants of concern.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Keyword
- hexabromocyclododecane
- enantiomeric separation
- supercritical fluid chromatography
Publication and Content Type
- ref (subject category)
- art (subject category)
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Riddell, Nicole, ...
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Mullin, Lauren G ...
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van Bavel, Bert, ...
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Ericson Jogsten, ...
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McAlees, Alan
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Brazeau, Allison
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Synnott, Scott
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Lough, Alan
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McCrindle, Rober ...
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Chittim, Brock
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Analytical Chemi ...
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Molecules
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Örebro University