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Influence of GABA a...
Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model
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- Marques, Tatiana M., 1980- (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Moorepark, Teagasc Food Research Centre, Fermoy, Ireland; School of Microbiology, University College Cork, Cork, Ireland
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- Patterson, E. (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Moorepark, Teagasc Food Research Centre, Fermoy, Ireland; School of Microbiology, University College Cork, Cork, Ireland
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- Wall, Rebecca, 1979- (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
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- O'Sullivan, O. (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland
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- Fitzgerald, G. F. (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland
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- Cotter, P. D. (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland
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- Dinan, T. G. (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland
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- Cryan, J. F. (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland
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- Ross, R. P. (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland
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- Stanton, C. (author)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland
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(creator_code:org_t)
- Wageningen, Netherlands : Wageningen Academic Publishers, 2016
- 2016
- English.
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In: Beneficial Microbes. - Wageningen, Netherlands : Wageningen Academic Publishers. - 1876-2883 .- 1876-2891. ; 7:3, s. 409-420
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- The aim of this study was to investigate if dietary administration of γ-aminobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA exert protective effects against the development of diabetes in streptozotocin (STZ)-induced diabetic Sprague Dawley rats. In a first experiment, healthy rats were divided in 3 groups (n=10/group) receiving placebo, 2.6 mg/kg body weight (bw) pure GABA or L. brevis DPC 6108 (~10(9)microorganisms). In a second experiment, rats (n=15/group) were randomised to five groups and four of these received an injection of STZ to induce type 1 diabetes. Diabetic and non-diabetic controls received placebo [4% (w/v) yeast extract in dH2O], while the other three diabetic groups received one of the following dietary supplements: 2.6 mg/kg bw GABA (low GABA), 200 mg/kg bw GABA (high GABA) or ~10(9) L. brevis DPC 6108. L. brevis DPC 6108 supplementation was associated with increased serum insulin levels (P<0.05), but did not alter other metabolic markers in healthy rats. Diabetes induced by STZ injection decreased body weight (P<0.05), increased intestinal length (P<0.05) and stimulated water and food intake. Insulin was decreased (P<0.05), whereas glucose was increased (P<0.001) in all diabetic groups, compared with non-diabetic controls. A decrease (P<0.01) in glucose levels was observed in diabetic rats receiving L. brevis DPC 6108, compared with diabetic-controls. Both the composition and diversity of the intestinal microbiota were affected by diabetes. Microbial diversity in diabetic rats supplemented with low GABA was not reduced (P>0.05), compared with non-diabetic controls while all other diabetic groups displayed reduced diversity (P<0.05). L. brevis DPC 6108 attenuated hyperglycaemia induced by diabetes but additional studies are needed to understand the mechanisms involved in this reduction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Streptozotocin
- type-1 diabetes
- probiotic
- γ-aminobutyric acid
Publication and Content Type
- ref (subject category)
- art (subject category)
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Marques, Tatiana ...
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Patterson, E.
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Wall, Rebecca, 1 ...
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O'Sullivan, O.
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Fitzgerald, G. F ...
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Cotter, P. D.
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Dinan, T. G.
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Cryan, J. F.
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Ross, R. P.
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Stanton, C.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Beneficial Micro ...
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Örebro University