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Childhood attention...
Childhood attention-deficit/hyperactivity disorder symptoms and the development of adolescent alcohol problems : A prospective, population-based study of Swedish twins
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- Quinn, Patrick D. (author)
- Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA
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- Pettersson, Erik (author)
- Karolinska Institutet
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- Lundström, Sebastian (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden
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- Anckarsäter, Henrik, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden
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- Långström, Niklas (author)
- Karolinska Institutet
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- Gumpert, Clara Hellner (author)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (author)
- Karolinska Institutet
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- Lichtenstein, Paul (author)
- Karolinska Institutet
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- D'Onofrio, Brian M. (author)
- Karolinska Institutet
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- ISSN 1552-485X
- 2015-12-30
- 2016
- English.
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In: American Journal of Medical Genetics Part B. - Hoboken, USA : John Wiley & Sons. - 1552-4841 .- 1552-485X. ; 171:7, s. 958-970
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Abstract
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- Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of problematic alcohol and other substance use in adolescence. This study used data from an ongoing, prospective, population-based twin study of Swedish children and adolescents to evaluate the extent to which the association between ADHD symptoms and alcohol problems reflects a unique source of genetic or environmental risk related to ADHD versus a broader predisposition to youth externalizing behavior. We used all available data from same-sex monozygotic (MZ) and dizygotic (DZ) twins on ADHD symptoms in childhood (age 9/12; N = 15,549) and alcohol problems in late adolescence (age 18; N = 2,564). Consistent with prior longitudinal studies, the phenotypic association between hyperactive/impulsive ADHD symptoms and alcohol problems was small in magnitude, whereas the association for inattentive symptoms was even weaker. Additive genetic influences explained 99.8% of the association between hyperactive/impulsive symptoms and alcohol problems. Furthermore, we found that the genetic risk specifically associated with hyperactive/impulsive symptoms was attenuated when estimated in the context of externalizing behavior liability during childhood, of which ADHD symptoms were specific expressions. In sensitivity analyses exploring hyperactivity in mid-adolescence, we found a similar pattern of genetic associations. These results are consistent with previous findings of genetically driven overlap in the etiology of ADHD and problematic alcohol use. At least some of this co-occurrence may result from a general predisposition to externalizing behaviors in youth. © 2015 Wiley Periodicals, Inc.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Quinn, Patrick D ...
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Pettersson, Erik
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Lundström, Sebas ...
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Anckarsäter, Hen ...
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Långström, Nikla ...
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Gumpert, Clara H ...
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Larsson, Henrik, ...
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Lichtenstein, Pa ...
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D'Onofrio, Brian ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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American Journal ...
- By the university
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Örebro University
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Karolinska Institutet
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University of Gothenburg