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Can probiotics modu...
Can probiotics modulate human disease by impacting intestinal barrier function?
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- Bron, Peter A. (author)
- NIZO Food Research, Ede, The Netherlands; BE-Basic Foundation, The Netherlands, Delft, The Netherlands
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- Kleerebezem, Michiel (author)
- Host Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands
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- Brummer, Robert-Jan, 1957- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
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- Cani, Patrice D. (author)
- Metabolism and Nutrition Research Group, WELBIO – Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium
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- Mercenier, Annick (author)
- Nutrition and Health Research, Nestlé Research Center, Lausanne, Switzerland
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- MacDonald, Thomas T. (author)
- Barts and The London school of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK
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- Garcia-Ródenas, Clara L (author)
- Nutrition and Health Research, Nestlé Research Center, Lausanne, Switzerland
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- Wells, Jerry M. (author)
- Host Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands
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(creator_code:org_t)
- Cambridge, United Kingdom : Cambridge University Press, 2017
- 2017
- English.
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In: British Journal of Nutrition. - Cambridge, United Kingdom : Cambridge University Press. - 0007-1145 .- 1475-2662. ; 117:1, s. 93-107
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Probiotics
- Gut microbiota
- Gut barrier
- Immunity
- Gastrointestinal disorders
Publication and Content Type
- ref (subject category)
- for (subject category)
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