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Lactase persistence...
Lactase persistence and milk consumption are associated with body height in Swedish preadolescents and adolescents
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- Almon, Ricardo, 1965- (author)
- Örebro universitet,Hälsoakademin
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- Nilsson, Torbjörn K (author)
- Dept Lab Med, Örebro Univ Hosp, Örebro, Sweden,Department of Laboratory Medicine, Clinical Chemistry, Örebro University Hospital, Örebro, Sweden
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- Sjöström, Michael (author)
- Karolinska Institutet,Unit Prevent Nutr, Dept Biosci & Nutr, Karolinska Institute, Huddinge, Sweden
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- Engfeldt, Peter, 1947- (author)
- Örebro universitet,Hälsoakademin
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(creator_code:org_t)
- 2017-01-17
- 2011
- English.
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In: Food & Nutrition Research. - : CoAction Publishing. - 1654-6628 .- 1654-661X. ; 55
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Abstract
Subject headings
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- Background: Body height is a classic polygenic trait. About 80%-90% of height is inherited and 10%-20% owed to environmental factors, of which the most important ones are nutrition and diseases in preadolescents and adolescents.Objective: The aim of this study was to explore potential relations between the LCT (lactase) C > T-13910 polymorphism, milk consumption, and body height in a sample of Swedish preadolescents and adolescents.Design: In a cross-sectional study, using a random sample of preadolescents and adolescents (n = 597), dietary intakes were determined. Anthropometric measurements including sexual maturity (Tanner stage) and birth weight were assessed. Parental body height and socio-economic status (SES) were obtained by questionnaires. Genotyping for the LCT C > T-13910 polymorphism that renders individuals lactase persistent (LP) or lactase non-persistent (LNP) was performed by DNA sequencing. Stepwise backward multivariate linear regression was used.Results: Milk consumption was significantly and positively associated with body height (beta =0.45; 95% CI: 0.040, 0.87, p =0.032). Adjustments were performed for sex, parental height, birth weight, body mass index (BMI), SES, and Tanner stage. This model explains 90% of the observed variance of body height (adjusted R-2 =0.89). The presence of the -13910 T allele was positively associated with body height (beta = 2.05; 95% CI: 0.18, 3.92, p =0.032).Conclusions: Milk consumption is positively associated with body height in preadolescents and adolescents. We show for the first time that a nutrigenetic variant might be able to explain in part phenotypic variation of body height in preadolescents and adolescents. Due to the small sample size further studies are needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- LCT-13910 C > T polymorphism
- body height
- milk consumption
- parental body height
Publication and Content Type
- ref (subject category)
- art (subject category)
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