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Characterization and prognostic features of secondary acute myeloid leukemia in a population-based setting : A report from the Swedish Acute Leukemia Registry

Hulegardh, Erik (author)
Dept Med, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Reg Tumor Registry, Sahlgrenska Univ Hosp, Gothenburg, Sweden,Sahlgrens University Hospital, Sweden; Sahlgrens University Hospital, Sweden
Nilsson, Christer (author)
Karolinska Institutet
Lazarevic, Vladimir (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Swedish Acute Myeloid Leukemia Grp; Skåne University Hospital, Sweden; Skåne University Hospital, Sweden; Lund University, Sweden
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Garelius, Hege (author)
Dept Med, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Reg Tumor Registry, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Swedish Acute Myeloid Leukemia Grp, Linköping Univ Hosp, Linköping, Sweden,Swedish Acute Myeloid Leukemia Grp; Sahlgrens University Hospital, Sweden; Sahlgrens University Hospital, Sweden
Antunovic, Petar (author)
Linköpings universitet,Medicinska fakulteten,Avdelningen för kliniska vetenskaper,Region Östergötland, Hematologiska kliniken US,Swedish Acute Myeloid Leukemia Grp
Rangert Derolf, Asa (author)
Swedish Acute Myeloid Leukemia Grp, Linköping Univ Hosp, Linköping, Sweden; Ctr Hematol, Karolinska Univ Hosp, Stockholm, Sweden; Reg Tumor Registry, Karolinska Univ Hosp, Stockholm, Sweden,Swedish Acute Myeloid Leukemia Grp; Karolinska University Hospital, Sweden; Karolinska University Hospital, Sweden
Mollgard, Lars (author)
Dept Med, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Reg Tumor Registry, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Swedish Acute Myeloid Leukemia Grp, Linköping Univ Hosp, Linköping, Sweden,Swedish Acute Myeloid Leukemia Grp; Sahlgrens University Hospital, Sweden; Sahlgrens University Hospital, Sweden
Uggla, Bertil, 1962- (author)
Region Örebro län,Swedish Acute Myeloid Leukemia Group, Linköping, Sweden; Department of Medicine, Örebro University Hospital, Örebro, Sweden
Wennström, Lovisa (author)
Dept Med, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Reg Tumor Registry, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Swedish Acute Myeloid Leukemia Grp, Linköping Univ Hosp, Linköping, Sweden,Swedish Acute Myeloid Leukemia Grp; Sahlgrens University Hospital, Sweden; Sahlgrens University Hospital, Sweden
Wahlin, Anders (author)
Umeå universitet,Institutionen för strålningsvetenskaper,Swedish Acute Myeloid Leukemia Grp; Umeå University, Sweden; Norrland University Hospital, Sweden
Höglund, Martin (author)
Uppsala universitet,Hematologi,Swedish Acute Myeloid Leukemia Grp; Academic Hospital, Sweden; Academic Hospital, Sweden
Juliusson, Gunnar (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden; Skåne University Hospital, Sweden; Lund University, Sweden;Swedish Acute Myeloid Leukemia Grp
Stockelberg, Dick (author)
Dept Med, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Reg Tumor Registry, Sahlgrenska Univ Hosp, Gothenburg, Sweden; Swedish Acute Myeloid Leukemia Grp, Linköping Univ Hosp, Linköping, Sweden,Swedish Acute Myeloid Leukemia Grp; Sahlgrens University Hospital, Sweden; Sahlgrens University Hospital, Sweden
Lehmann, Sören (author)
Karolinska Institutet,Uppsala universitet,Hematologi,Swedish Acute Myeloid Leukemia Grp; Karolinska University Hospital, Sweden
Swedish Acute Myeloid Leukemia Grp,, Group author (author)
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 (creator_code:org_t)
2015-01-16
2015
English.
In: American Journal of Hematology. - : Wiley-Blackwell. - 0361-8609 .- 1096-8652. ; 90:3, s. 208-214
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Patients with secondary acute myeloid leukemia (AML) often escape inclusion in clinical trials and thus, population-based studies are crucial for its accurate characterization. In this first large population-based study on secondary AML, we studied AML with an antecedent hematological disease (AHD-AML) or therapy-related AML (t-AML) in the population-based Swedish Acute Leukemia Registry. The study included 3,363 adult patients of which 2,474 (73.6%) had de novo AML, 630 (18.7%) AHD-AML, and 259 (7.7%) t-AML. Secondary AML differed significantly compared to de novo AML with respect to age, gender, and cytogenetic risk. Complete remission (CR) rates were significantly lower but early death rates similar in secondary AML. In a multivariable analysis, AHD-AML (HR 1.51; 95% CI 1.26-1.79) and t-AML (1.72; 1.38-2.15) were independent risk factors for poor survival. The negative impact of AHD-AML and t-AML on survival was highly age dependent with a considerable impact in younger patients, but without independent prognostic value in the elderly. Although patients with secondary leukemia did poorly with intensive treatment, early death rates and survival were significantly worse with palliative treatment. We conclude that secondary AML in a population-based setting has a striking impact on survival in younger AML patients, whereas it lacks prognostic value among the elderly patients. Am. J. Hematol. 90:208-214, 2015.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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