High In Vitro Activity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea

Jacobsson, Susanne,1974-Region Örebro län,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden (author)

Funding Agencies:Örebro County Council Research CommitteeFoundation for Medical Research at Örebro University Hospital, SwedenInfection iMed, AstraZeneca Pharmaceuticals LP, Waltham, MA
We evaluated the activity of the novel spiropyrimidinetrione AZD0914 (DNA gyrase inhibitor) against clinical gonococcal isolates and international reference strains (n = 250), including strains with diverse multidrug resistance and extensive drug resistance. The AZD0914 MICs were substantially lower than those of most other currently or previously recommended antimicrobials. AZD0914 should be further evaluated, including in vitro selection, in vivo emergence and mechanisms of resistance, pharmacokinetics/pharmacodynamics in humans, optimal dosing, and performance, in appropriate randomized and controlled clinical trials.

Golparian, Daniel,1984-National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden(Swepub:oru)degn (author)
Alm, Richard A.Infection IMed, AstraZeneca RandD Boston, Waltham MA, United States (author)
Huband, MichaelInfection IMed, AstraZeneca RandD Boston, Waltham MA, United States (author)
Mueller, JohnInfection IMed, AstraZeneca RandD Boston, Waltham MA, United States (author)
Jensen, Jorgen SkovStatens Serum Institut, Copenhagen, Denmark (author)
Ohnishi, MakotoNational Institute of Infectious Diseases, Tokyo, Japan (author)
Unemo, Magnus,1970-Region Örebro län,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden(Swepub:oru)muo (author)
Region Örebro länNational Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden (creator_code:org_t)

In:Antimicrobial Agents and Chemotherapy: American Society for Microbiology58:9, s. 5585-55880066-48041098-6596

By the author/editor: Jacobsson, Susan ...; Golparian, Danie ...; Alm, Richard A.; Huband, Michael; Mueller, John; Jensen, Jorgen S ...; show more...; Ohnishi, Makoto; Unemo, Magnus, 1 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

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