Search: onr:"swepub:oai:DiVA.org:oru-56454" > High In Vitro Activ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03725naa a2200397 4500 | |
001 | oai:DiVA.org:oru-56454 | |
003 | SwePub | |
008 | 170316s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-564542 URI |
024 | 7 | a https://doi.org/10.1128/AAC.03090-142 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jacobsson, Susanne,d 1974-u Region Örebro län,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)sajn |
245 | 1 0 | a High In Vitro Activity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea |
264 | 1 | b American Society for Microbiology,c 2014 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Örebro County Council Research CommitteeFoundation for Medical Research at Örebro University Hospital, SwedenInfection iMed, AstraZeneca Pharmaceuticals LP, Waltham, MA | |
520 | a We evaluated the activity of the novel spiropyrimidinetrione AZD0914 (DNA gyrase inhibitor) against clinical gonococcal isolates and international reference strains (n = 250), including strains with diverse multidrug resistance and extensive drug resistance. The AZD0914 MICs were substantially lower than those of most other currently or previously recommended antimicrobials. AZD0914 should be further evaluated, including in vitro selection, in vivo emergence and mechanisms of resistance, pharmacokinetics/pharmacodynamics in humans, optimal dosing, and performance, in appropriate randomized and controlled clinical trials. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
700 | 1 | a Golparian, Daniel,d 1984-u National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)degn |
700 | 1 | a Alm, Richard A.u Infection IMed, AstraZeneca RandD Boston, Waltham MA, United States4 aut |
700 | 1 | a Huband, Michaelu Infection IMed, AstraZeneca RandD Boston, Waltham MA, United States4 aut |
700 | 1 | a Mueller, Johnu Infection IMed, AstraZeneca RandD Boston, Waltham MA, United States4 aut |
700 | 1 | a Jensen, Jorgen Skovu Statens Serum Institut, Copenhagen, Denmark4 aut |
700 | 1 | a Ohnishi, Makotou National Institute of Infectious Diseases, Tokyo, Japan4 aut |
700 | 1 | a Unemo, Magnus,d 1970-u Region Örebro län,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)muo |
710 | 2 | a Region Örebro länb National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden4 org |
773 | 0 | t Antimicrobial Agents and Chemotherapyd : American Society for Microbiologyg 58:9, s. 5585-5588q 58:9<5585-5588x 0066-4804x 1098-6596 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56454 |
856 | 4 8 | u https://doi.org/10.1128/AAC.03090-14 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Copy and save the link in order to return to this view