Russian gonococcal antimicrobial susceptibility programme (RU-GASP) - resistance in Neisseria gonorrhoeae during 2009-2012 and NG-MAST genotypes in 2011 and 2012

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Russian gonococcal antimicrobial susceptibility programme (RU-GASP) - resistance in Neisseria gonorrhoeae during 2009-2012 and NG-MAST genotypes in 2011 and 2012

Kubanova, Anna (author): State Res Ctr Dermatol Venereol & Cosmetol, Russian Minist Hlth SRCDVC, Moscow, Russia

Kubanov, Alexey (author): State Res Ctr Dermatol Venereol & Cosmetol, Russian Minist Hlth SRCDVC, Moscow, Russia

Frigo, Nataliya (author): State Res Ctr Dermatol Venereol & Cosmetol, Russian Minist Hlth SRCDVC, Moscow, Russia

Solomka, Viktoria (author): State Res Ctr Dermatol Venereol & Cosmetol, Russian Minist Hlth SRCDVC, Moscow, Russia

Semina, Vera (author): State Res Ctr Dermatol Venereol & Cosmetol, Russian Minist Hlth SRCDVC, Moscow, Russia

Vorobyev, Denis (author): State Res Ctr Dermatol Venereol & Cosmetol, Russian Minist Hlth SRCDVC, Moscow, Russia

Khairullin, Rafil (author): State Res Ctr Dermatol Venereol & Cosmetol, Russian Minist Hlth SRCDVC, Moscow, Russia

Unemo, Magnus, 1970- (author): Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden

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2014-06-19
2014
English.
In: BMC Infectious Diseases. - : BioMed Central. - 1471-2334. ; 14

Related links:: https://doi.org/10.1...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major concern worldwide and gonococcal AMR surveillance globally is imperative for public health purposes. In Eastern Europe, gonococcal AMR surveillance is exceedingly rare. However, in 2004 the Russian gonococcal antimicrobial susceptibility programme (RU-GASP) was initiated. The aims of this study were to describe the prevalence and trends of gonococcal AMR from 2009 to 2012, and molecular epidemiological genotypes in 2011 and 2012 in Russia.Methods: Gonococcal isolates from 12-46 surveillance sites distributed across Russia, obtained in 2009 (n = 1200), 2010 (n = 407), 2011 (n = 423), and 2012 (n = 106), were examined for antimicrobial susceptibility using agar dilution method. Gonococcal isolates from 2011 and 2012 were investigated with N. gonorrhoeae multi-antigen sequence typing (NG-MAST).Results: During 2009-2012, the proportions of gonococcal isolates resistant to ciprofloxacin, penicillin G, azithromycin and spectinomycin ranged from 25.5% to 44.4%, 9.6% to 13.2%, 2.3% to 17.0% and 0.9% to 11.6%, respectively. Overall, the resistance level to penicillin G was stable, the resistance level to ciprofloxacin was decreasing, however, the level of resistance to azithromycin increased. All isolates were susceptible to ceftriaxone using the US CLSI breakpoints. However, using the European breakpoints 58 (2.7%) of the isolates were resistant to ceftriaxone. Interestingly, this proportion was decreasing, i.e. from 4.8% in 2009 to 0% in 2012.Conclusions: In Russia, the diversified gonococcal population showed a high resistance to ciprofloxacin, penicillin G and azithromycin. In general, the MICs of ceftriaxone were relatively high, however, they were decreasing from 2009 to 2012. Ceftriaxone should be the first-line for empiric antimicrobial monotherapy of gonorrhoea in Russia. It is essential to further strengthen the surveillance of gonococcal AMR (ideally also gonorrhoea treatment failures) in Russia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

Neisseria gonorrhoeae
Gonorrhoea
Antimicrobial resistance
National surveillance
Russian gonococcal antimicrobial susceptibility programme (RU-GASP)
Extended-spectrum cephalosporins (ESCs)
Ceftriaxone
Treatment
N. gonorrhoeae multiantigen sequence typing (NG-MAST)
Russia

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art (subject category)

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By the author/editor: Kubanova, Anna; Kubanov, Alexey; Frigo, Nataliya; Solomka, Viktori ...; Semina, Vera; Vorobyev, Denis; show more...; Khairullin, Rafi ...; Unemo, Magnus, 1 ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

Articles in the publication: BMC Infectious D ...

By the university: Örebro University

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