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Arm lymphoedema aft...
Arm lymphoedema after axillary surgery in women with invasive breast cancer
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- Sackey, H. (author)
- Karolinska Institutet
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- Magnuson, A. (author)
- Clinical Epidemiology and Biostatistics
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- Sandelin, K. (author)
- Karolinska Institutet
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- Liljegren, Göran, 1948- (author)
- Region Örebro län,Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Bergkvist, Leif (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Institutionen för kirurgiska vetenskaper
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- Fulep, Z. (author)
- Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Celebioglu, F. (author)
- Karolinska Institutet
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- Frisell, J. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2014-02-17
- 2014
- English.
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In: British Journal of Surgery. - : Wiley-Blackwell. - 0007-1323 .- 1365-2168. ; 101:4, s. 390-397
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The primary aim was to compare arm lymphoedema after sentinel lymph node biopsy (SLNB) alone versus axillary lymph node dissection (ALND) in women with node-negative and node-positive breast cancer. The secondary aim was to examine the potential association between self-reported and objectively measured arm lymphoedema.Methods: Women who had surgery during 1999-2004 for invasive breast cancer in four centres in Sweden were included. The study groups were defined by the axillary procedure performed and the presence of axillary metastases: SLNB alone, ALND without axillary metastases, and ALND with axillary metastases. Before surgery, and 1, 2 and 3years after operation, arm volume was measured and a questionnaire regarding symptoms of arm lymphoedema was completed. A mixed model was used to determine the adjusted mean difference in arm volume between the study groups, and generalized estimating equations were employed to determine differences in self-reported arm lymphoedema.Results: One hundred and forty women had SLNB alone, 125 had node-negative ALND and 155 node-positive ALND. Women who underwent SLNB had no increase in postoperative arm volume over time, whereas both ALND groups showed a significant increase. The risk of self-reported arm lymphoedema 1, 2 and 3years after surgery was significantly lower in the SLNB group compared with that in both ALND groups. Three years after surgery there was a significant association between increased arm volume and self-reported symptoms of arm lymphoedema.Conclusion: SLNB is associated with a minimal risk of increased arm volume and few symptoms of arm lymphoedema, significantly less than after ALND, regardless of lymph node status.Minimal after sentinel node biopsy
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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