Evolutionary epidemiology of Neisseria meningitidis strains in Belarus compared to other European countries

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Evolutionary epidemiology of Neisseria meningitidis strains in Belarus compared to other European countries

Titov, Leonid P. (author): Republ Res & Pract Ctr Epidemiol & Microbiol, Minsk, Byelarus

Siniuk, Kanstantsin V. (author): Republ Res & Pract Ctr Epidemiol & Microbiol, Minsk, Byelarus

Wollenberg, Kurt K. (author): National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda MD, USA

Unemo, Magnus (author): Region Örebro län,Dept Lab Med, Natl Reference Lab Pathogen Neisseria, Örebro University Hospital, Örebro, Sweden

Thulin Hedberg, Sara (author): Region Örebro län,Dept Lab Med, Natl Reference Lab Pathogen Neisseria, Örebro University Hospital, Örebro, Sweden

Glazkova, Slavyana E. (author): Republ Res & Pract Ctr Epidemiol & Microbiol, Minsk, Byelarus

Lebedzeu, Fiodar A. (author): Republ Res & Pract Ctr Epidemiol & Microbiol, Minsk, Byelarus

Nosava, Alena S. (author): Republ Res & Pract Ctr Epidemiol & Microbiol, Minsk, Byelarus

Yanovich, Volcha O. (author): Republ Res & Pract Ctr Epidemiol & Microbiol, Minsk, Byelarus

Xirasagar, Sadhia (author): National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda MD, USA

Hurt, Darrell (author): National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda MD, USA

Huyen, Yentram (author): National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda MD, USA

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2013
2013
English.
In: Acta Microbiologica et Immunologica Hungarica. - 1217-8950. ; 60:4, s. 397-410

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Introduction. Meningococcal infections are major causes of death in children globally. In Belarus, the incidence of cases and fatality rate of meningococcal infections are low and comparable to the levels in other European countries. Aim. In the present study, the molecular and epidemiological traits of Neisseria meningitidis strains circulating in Belarus were characterized and compared to isolates from other European countries. Materials and Methods. Twenty N. meningitidis strains isolated from patients (n = 13) and healthy contacts (n = 7) during 2006-2012 in Belarus were selected for multilocus sequence typing (MLST), genosubtyping and FetA typing. The STs of the Belarusian strains were phylogenetically compared to the STs of 110 selected strains from 22 other European countries. Results. Overall, eleven different genosubtypes were observed, there were seven variants of variable region of the fetA gene detected. The majority of the STs (95%) found in Belarus were novel and all those were submitted to the Neisseria MLST database for assignment. Several newly discovered alleles of fumC (allele 451) and gdh (allele 560 and 621) appeared to be descendants of alleles which are widespread in Europe, and single aroE alleles (602 and 603) occurred as a result of separate evolution. Conclusions. N. meningitidis strains circulating in Belarus are heterogeneous and include sequence types, possibly, locally evolved in Belarus as well as representatives of widespread European hyperinvasive clonal complexes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Neisseria meningitidis
multilocus sequence typing (MLST)
sequence type (ST)
clonal complex (CC)
evolution
Belarus

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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