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Search: onr:"swepub:oai:DiVA.org:oru-57401" > Incidence and progn...

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  • Lj Lazarevic, VladimirLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital (author)

Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia : A population-based study from the Swedish AML registry

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-03-09
  • John Wiley & Sons,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-57401
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57401URI
  • https://doi.org/10.1111/ejh.12861DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-135271URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-322686URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-137596URI
  • https://lup.lub.lu.se/record/fb73da16-5cf8-417b-9b9d-473773f33563URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135709815URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:Regional Cancer Centers Swedish Association of Local Authorities and Regions (SKL)  Governmental Funding of Clinical Research within the National Health Service 
  • Funding Agencies|Vetenskapsradet; Cancerfonden; Regional Cancer Centers; Swedish Association of Local Authorities and Regions (SKL); Governmental Funding of Clinical Research within the National Health Service
  • OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P<.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 (P=.013).CONCLUSION: AML with single trisomies, with the exception of +13, should be grouped as IR.

Subject headings and genre

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  • Rosso, AldanaKarolinska Institutet,Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)maxl-aro (author)
  • Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)stem-gju (author)
  • Antunovic, PetarLinköping University,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US(Swepub:liu)petan27 (author)
  • Derolf, Åsa RangertKarolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Div Hematol, Dept Med, Stockholm, Sweden. (author)
  • Deneberg, StefanKarolinska Institutet (author)
  • Möllgård, LarsSahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden. (author)
  • Uggla, Bertil,1962-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Orebro Univ Hosp, Sch Hlth & Med Sci, Dept Med, Orebro, Sweden.,Örebro University Hospital, Sweden(Swepub:oru)bua (author)
  • Wennström, LovisaSahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden. (author)
  • Wahlin, AndersUmeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden.,Umeå University, Sweden(Swepub:umu)anwa0027 (author)
  • Höglund, MartinUppsala universitet,Hematologi,Academic Hospital, Sweden,Uppsala University Hospital(Swepub:uu)martinhl (author)
  • Lehmann, SörenKarolinska Institutet,Uppsala universitet,Hematologi,Academic Hospital, Sweden,Uppsala University Hospital(Swepub:uu)sorle534 (author)
  • Johansson, BertilLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-bjo (author)
  • Stamcellscentrum (SCC)Avdelningen för stamcellsforskning (creator_code:org_t)

Related titles

  • In:European Journal of Haematology: John Wiley & Sons98:5, s. 493-5000902-44411600-0609

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