Search: onr:"swepub:oai:DiVA.org:oru-57434" >
Long-term efficacy ...
-
Nielsen, Jens CosedisAarhus Univ Hosp, Aarhus, Denmark,Aarhus University Hospital, Denmark
(author)
Long-term efficacy of catheter ablation as first-line therapy for paroxysmal atrial fibrillation : 5-year outcome in a randomised clinical trial.
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
2016-08-26
-
BMJ Publishing Group Ltd,2017
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:oru-57434
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57434URI
-
https://doi.org/10.1136/heartjnl-2016-309781DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133317URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Funding agenciesDanish Heart Foundation, grant no: 05-4-B284-A466-22237 Biosense Webster
-
Funding agencies: Danish Heart Foundation [05-4-B284-A466-22237]; Biosense Webster
-
OBJECTIVE: The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) trial compared radiofrequency catheter ablation (RFA) with antiarrhythmic drug therapy (AAD) as first-line treatment for paroxysmal atrial fibrillation (AF). Endpoint of ablation was elimination of electrical activity inside pulmonary veins. We present the results of the 5-year follow-up.METHODS: This pre-specified 5-year follow-up included assessment of any AF and symptomatic AF burden by one 7-day Holter recording and quality of life (QoL) assessment, using SF-36 questionnaire physical and mental component scores. Analysis was intention-to-treat. Imputation was used to compensate for missing Holter data.RESULTS: 245 of 294 patients (83%) randomised to RFA (n=125) or AAD (n=120) attended the 5-year follow-up, 227 with Holter recording. Use of class I or III AAD was more frequent in AAD group (N=61 vs 13, p<0.001). More patients in the RFA group were free from AF (126/146 (86%) vs 105/148 (71%), p=0.001, relative risk (RR) 0.82; 95% CI 0.73 to 0.93) and symptomatic AF (137/146 (94%) vs 126/148 (85%), p=0.015, χ(2) test, RR 0.91; 95% CI 0.84 to 0.98) in 7-day Holter recording. AF burden was significantly lower in the RFA group (any AF: p=0.003; symptomatic AF: p=0.02). QoL scores did not differ between randomisation groups. QoL scores remained improved from baseline (both components p<0.001), and did not differ from 2-year scores.CONCLUSIONS: At 5 years, the occurrence and burden of any AF and symptomatic AF were significantly lower in the RFA group than in the AAD group. Improved QoL scores observed after 2 years persisted after 5 years without between-group differences.TRIAL REGISTRATION NUMBER: NCT00133211; Results.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Johannessen, ArneGentofte University Hospital, Copenhagen, Denmark
(author)
-
Raatikainen, PekkaHeart Center Co. Tampere University Hospital, Tampere, Finland
(author)
-
Hindricks, GerhardLeipzig University Hospital, Leipzig, Germany
(author)
-
Walfridsson, HåkanLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)hakwa83
(author)
-
Pehrson, Steen MichaelDepartment of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, Denmark
(author)
-
Englund, AndersRegion Örebro län,Department of Medicine, Örebro University Hospital, Örebro, Sweden
(author)
-
Hartikainen, JuhaKuopio University Hospital, Kuopio, Finland
(author)
-
Mortensen, Leif SpangeUNI-C, Danish Information Technology Centre for Education and Research, Aarhus, Denmark
(author)
-
Mantra-Paf Investigators, Group Author
(author)
-
Steen Hansen, PeterMANTRA-PAF Investigators. UNI-C, Danish Information Technology Centre for Education and Research, Aarhus, Denmark
(author)
-
Aarhus Univ Hosp, Aarhus, DenmarkAarhus University Hospital, Denmark
(creator_code:org_t)
Related titles
-
In:Heart: BMJ Publishing Group Ltd103:5, s. 368-3761355-60371468-201X
Internet link
Find in a library
-
Heart
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Nielsen, Jens Co ...
-
Johannessen, Arn ...
-
Raatikainen, Pek ...
-
Hindricks, Gerha ...
-
Walfridsson, Håk ...
-
Pehrson, Steen M ...
-
show more...
-
Englund, Anders
-
Hartikainen, Juh ...
-
Mortensen, Leif ...
-
Mantra-Paf Inves ...
-
Steen Hansen, Pe ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Heart
- By the university
-
Örebro University
-
Linköping University