onr:"swepub:oai:DiVA.org:oru-59246"
Search: onr:"swepub:oai:DiVA.org:oru-59246" > Hormone replacement...
- 1 of 1
- Previous record
- Next record
- To hitlist
Hormone replacement therapy in relation to risk of cataract extraction : a prospective study of women
-
- Lindblad, Birgitta Ejdervik, 1955- (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, Sundsvall Hospital, Sundsvall, Sweden,Sundsvall Hosp, Dept Ophthalmol, SE-85186 Sundsvall, Sweden.;Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.
-
- Håkansson, Niclas (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.
-
- Philipson, Bo (author)
- Stockholm Eye Clinic, H.M. Queen Sophia Hospital, Stockholm, Sweden,HM Queen Sophia Hosp, Stockholm Eye Clin, Stockholm, Sweden.
- show more...
- show less...
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, Sundsvall Hospital, Sundsvall, Sweden Sundsvall Hosp, Dept Ophthalmol, SE-85186 Sundsvall, Sweden;Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden. (creator_code:org_t)
- Elsevier, 2010
- 2010
- English.
- In: Ophthalmology. - : Elsevier. - 0161-6420 .- 1549-4713. ; 117:3, s. 424-430
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- OBJECTIVE: To investigate the association between hormone replacement therapy (HRT) and the incidence of cataract extraction among postmenopausal women.DESIGN: Population-based, prospective cohort study.PARTICIPANTS: A total of 30 861 postmenopausal women participating in the Swedish Mammography Cohort, age 49 to 83 years, who completed a self-administered questionnaire in 1997 about hormone status, HRT, and lifestyle factors.METHODS: The women were followed from September 1997 through October 2005. The cohort was matched with registers of cataract extraction in the study area.MAIN OUTCOME MEASURES: Incident operative extraction of age-related cataract.RESULTS: We identified 4324 incident cases of cataract extractions during 98 months of follow-up. In multivariate adjusted analysis, ever use of HRT was associated with a 14% increased risk of cataract extraction (rate ratio [RR], 1.14; 95% confidence interval [CI], 1.07-1.21) compared with those who never used HRT. Current use of HRT was associated with an 18% increased risk of cataract extraction (RR, 1.18; 95% CI, 1.10-1.26). A significant linear trend was observed where increasing duration of HRT usage resulted in an increased risk of cataract extraction (P for trend = 0.006). Multivariate RR for current HRT usage for >10 years was 1.20 (95% CI, 1.06-1.36; P for trend = 0.001). Among women drinking on average >1 drink of alcohol per day, current HRT users had a 42% increased risk (RR, 1.42; 95% CI, 1.11-1.80) for cataract extraction, compared with women who neither used HRT nor alcohol. The risk of cataract extraction among current users of HRT was similar among current smokers and those who never smoked.CONCLUSIONS: Our prospective, population-based study indicates that postmenopausal women using HRT for a long period of time may be at an increased risk for cataract extraction, especially those drinking >1 alcoholic drink daily.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Ophthalmology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Lindblad, Birgit ...
- Håkansson, Nicla ...
- Philipson, Bo
- Wolk, Alicja
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Ophthalmology
- Articles in the publication
- Ophthalmology
- By the university
- Örebro University
- Karolinska Institutet
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
