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Sökning: onr:"swepub:oai:DiVA.org:oru-59354" > Association of lipi...

Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans

Pietiläinen, Kirsi H (författare)
Department of Medicine, Division of Internal Medicine, Department of Psychiatry, Obesity Research Unit, Helsinki University Central Hospital, Helsinki, Finland; Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland, Helsinki, Finland
Róg, Tomasz (författare)
Department of Physics, Tampere University of Technology, Tampere, Finland
Seppänen-Laakso, Tuulikki (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
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Virtue, Sam (författare)
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Gopalacharyulu, Peddinti (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Tang, Jing (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Rodriguez-Cuenca, Sergio (författare)
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Maciejewski, Arkadiusz (författare)
Department of Physics, Tampere University of Technology, Tampere, Finland; Department of Computational Biophysics and Bioinformatics, Jagiellonian University, Kraków, Poland
Naukkarinen, Jussi (författare)
Department of Medical Genetics, University of Helsinki, Helsinki, Finland; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
Ruskeepää, Anna-Liisa (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Niemelä, Perttu S (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Yetukuri, Laxman (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Tan, Chong Yew (författare)
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Velagapudi, Vidya (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Castillo, Sandra (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Nygren, Heli (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland
Rissanen, Aila (författare)
Department of Medicine, Division of Internal Medicine, Department of Psychiatry, Obesity Research Unit, Helsinki University Central Hospital, Helsinki, Finland
Kaprio, Jaakko (författare)
Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland, Helsinki, Finland; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
Yki-Järvinen, Hannele (författare)
Division of Diabetes, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Vattulainen, Ilpo (författare)
Department of Physics, Tampere University of Technology, Tampere, Finland; Department of Applied Physics, School of Science and Technology, Aalto University, Espoo, Finland; MEMPHYS-Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark
Vidal-Puig, Antonio (författare)
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Oresic, Matej, 1967- (författare)
Institute for Molecular Medicine Finland, Helsinki, Finland; VTT Technical Research Centre of Finland, Espoo, Finland
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 (creator_code:org_t)
2011-06-07
2011
Engelska.
Ingår i: PLoS biology. - : Public Library of Science. - 1544-9173 .- 1545-7885. ; 9:6
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Identification of early mechanisms that may lead from obesity towards complications such as metabolic syndrome is of great interest. Here we performed lipidomic analyses of adipose tissue in twin pairs discordant for obesity but still metabolically compensated. In parallel we studied more evolved states of obesity by investigating a separated set of individuals considered to be morbidly obese. Despite lower dietary polyunsaturated fatty acid intake, the obese twin individuals had increased proportions of palmitoleic and arachidonic acids in their adipose tissue, including increased levels of ethanolamine plasmalogens containing arachidonic acid. Information gathered from these experimental groups was used for molecular dynamics simulations of lipid bilayers combined with dependency network analysis of combined clinical, lipidomics, and gene expression data. The simulations suggested that the observed lipid remodeling maintains the biophysical properties of lipid membranes, at the price, however, of increasing their vulnerability to inflammation. Conversely, in morbidly obese subjects, the proportion of plasmalogens containing arachidonic acid in the adipose tissue was markedly decreased. We also show by in vitro Elovl6 knockdown that the lipid network regulating the observed remodeling may be amenable to genetic modulation. Together, our novel approach suggests a physiological mechanism by which adaptation of adipocyte membranes to adipose tissue expansion associates with positive energy balance, potentially leading to higher vulnerability to inflammation in acquired obesity. Further studies will be needed to determine the cause of this effect.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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