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  • Aho, VilmaDepartment of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland (author)

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-04-22
  • Nature Publishing Group,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-59377
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59377URI
  • https://doi.org/10.1038/srep24828DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:EU  LSHM-CT-2005-518189  QLK6-CT-2000-00499 Finska Läkaresällskapet  Finnish Work Environment Fund  Yrjo Jahnsson Foundation  Orion Research Foundation  Jenny and Antti Wihuri Foundation  Finnish Foundation for Cardiovascular Research  Liv och Hälsa Foundation  Magnus Ehrnrooth Foundation  Diabetes Research Foundation  Sigrid Juselius Foundation  Helsinki University Central Hospital research funds  TYH6254 Carlos III Health Institute of the Spanish Ministry of Health  Academy of Finland  118065  138201  283045  139635  137870  257545  250114  137575  134309  126925  121584  124282  129378  117797  41071 Academy of Finland  TEKES - the Finnish Funding Agency for Technology and Innovation  Novo Nordisk Foundation  Finnish Diabetes Research Foundation  University of Oulu, Finland  British Heart Foundation  Welcome Trust  Medical Research Council, UK  Social Insurance Institution of Finland  Kuopio, Tampere and Turku University Hospital Medical Funds  Juho Vainio Foundation  Paavo Nurmi Foundation  Finnish Foundation of Cardiovascular Research  Finnish Cultural Foundation  Tampere Tuberculosis Foundation Emil Aaltonen Foundation
  • Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.

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  • Ollila, Hanna MDepartment of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Stanford University Center for Sleep Sciences, Palo Alto CA, United States (author)
  • Kronholm, ErkkiDepartment of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Finland (author)
  • Bondia-Pons, IsabelVTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center A/S, Gentofte, Denmark (author)
  • Soininen, PasiComputational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland (author)
  • Kangas, Antti JComputational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland (author)
  • Hilvo, MikaVTT Technical Research Centre of Finland, Espoo, Finland (author)
  • Seppälä, IlkkaDepartment of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland (author)
  • Kettunen, JohannesGenomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland (author)
  • Oikonen, MerviResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland (author)
  • Raitoharju, EmmaDepartment of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland (author)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center A/S, Gentofte, Denmark(Swepub:oru)tihn (author)
  • Kähönen, MikaDepartment of Clinical Physiology, University of Tampere, Tampere University Hospital, Tampere, Finland (author)
  • Viikari, Jorma S ADepartment of Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland (author)
  • Härmä, MikkoBrain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland (author)
  • Sallinen, MikaelBrain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland; Agora Center, University of Jyväskylä, Jyväskylä, Finland (author)
  • Olkkonen, Vesa MMinerva Foundation Institute for Medical Research, Helsinki, Finland; Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland (author)
  • Alenius, HarriUnit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland (author)
  • Jauhiainen, MattiGenomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland (author)
  • Paunio, TiinaGenomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (author)
  • Lehtimäki, TerhoDepartment of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland (author)
  • Salomaa, VeikkoDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (author)
  • Orešič, Matej,1967-VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center A/S, Gentofte, Denmark(Swepub:oru)moc (author)
  • Raitakari, Olli TResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland (author)
  • Ala-Korpela, MikaComputational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Oulu University Hospital, Oulu, Finland; Computational Medicine, School of Social and Community Medicine, Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (author)
  • Porkka-Heiskanen, TarjaDepartment of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland (author)
  • Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, FinlandDepartment of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Stanford University Center for Sleep Sciences, Palo Alto CA, United States (creator_code:org_t)

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  • In:Scientific Reports: Nature Publishing Group62045-2322

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