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Antimicrobial susce...
Antimicrobial susceptibility in Neisseria gonorrhoeae isolates from five sentinel surveillance sites in Zimbabwe, 2015-2016
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- Latif, Ahmed S. (author)
- Public Health Consultant, Brisbane, Australia
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- Gwanzura, Lovemore (author)
- Department of Medical Laboratory Sciences, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
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- Machiha, Anna (author)
- STI, HIV/AIDS and TB Programmes, Ministry of Health and Child Care, Harare, Zimbabwe
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- Ndowa, Francis (author)
- STI, HIV/AIDS and TB Programmes, Ministry of Health and Child Care, Harare, Zimbabwe
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- Tarupiwa, Andrew (author)
- National Microbiology Reference Laboratory, Harare, Zimbabwe
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- Gudza-Mugabe, Muchaneta (author)
- National Microbiology Reference Laboratory, Harare, Zimbabwe
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- Shukusho, Fungai D. (author)
- National Microbiology Reference Laboratory, Harare, Zimbabwe
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- Chakanyuka Musanhu, Christine (author)
- Country Office, World Health Organization, Harare, Zimbabwe
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- Wi, Teodora (author)
- Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
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- Unemo, Magnus, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2017-05-05
- 2018
- English.
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In: Sexually Transmitted Infections. - : BMJ Publishing Group Ltd. - 1368-4973 .- 1472-3263. ; 94:1, s. 62-66
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVES: Gonorrhoea and antimicrobial resistance (AMR) in Neisseria gonorrhoeae are major public health concerns worldwide. Enhanced AMR surveillance for gonococci is essential globally. In Zimbabwe, very limited gonococcal AMR data were reported. Our aims were to (i) implement quality-assured gonococcal AMR surveillance in Zimbabwe and (ii) investigate gonococcal AMR at five health centres in 2015-2016.METHODS: Gonococcal isolates from 104 men with urethral discharge were tested for susceptibility to kanamycin, ceftriaxone, cefixime, ciprofloxacin and azithromycin using Etest.RESULTS: All isolates (102 possible to test) were susceptible to ceftriaxone and cefixime. The level of resistance (intermediate resistance) to kanamycin and ciprofloxacin was 2.0% (2.0%) and 18.6% (27.5%), respectively. The two kanamycin-resistant isolates (R≥128 mg/L) had a kanamycin minimum inhibitory concentration (MIC) of >256 mg/L. The ciprofloxacin resistance ranged from 9.5% to 30.8% in the five sentinel sites. Only 10 (9.6%) of the isolates were tested for susceptibility to azithromycin and 1 (10.0%) was resistant (MIC=4 mg/L).CONCLUSIONS: The emergence of multidrug-resistant gonorrhoea internationally is a major public health concern and gonococcal AMR surveillance is crucial globally. In Zimbabwe, gonococcal AMR surveillance has now been implemented and quality assured according to WHO standards. The results of this first surveillance will be used to directly inform revisions of the national treatment guidelines. It is imperative to further strengthen the surveillance of gonococcal AMR, and ideally also treatment failures, in Zimbabwe and most countries in the WHO African region, which requires continuous national and international support, including technical support, and political and financial commitment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Africa
- antimicrobial resistance
- gonorrhoea
- neisseria gonorrhoea
- treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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Latif, Ahmed S.
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Gwanzura, Lovemo ...
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Machiha, Anna
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Ndowa, Francis
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Tarupiwa, Andrew
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Gudza-Mugabe, Mu ...
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Shukusho, Fungai ...
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Chakanyuka Musan ...
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Wi, Teodora
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Unemo, Magnus, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Sexually Transmi ...
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Örebro University