Patients without comorbidities at the time of diagnosis of atrial fibrillation: causes of death during long-term follow-up compared to matched controls

Andersson, Tommy,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sch Med Sci, Dept Cardiol, Orebro, Sweden. (author)

Patients without comorbidities at the time of diagnosis of atrial fibrillation : causes of death during long-term follow-up compared to matched controls

Funding Agency:Örebro Heart Foundation Research Committee of Örebro University Hospital, Sweden
BACKGROUND: Little is known about the long-term, cause-specific mortality risk in patients without comorbidities at the time of diagnosis of atrial fibrillation (AF).METHODS: From a nation-wide registry of patients hospitalized with incident AF between 1995 and 2008 we identified 9 519 patients with a first diagnosed AF and no comorbidities at the time of AF diagnosis. They were matched with 12 468 controls. The follow-up continued until December 2008. Causes of death were classified according to the ICD-10 codes.RESULTS: During follow-up, 11.1% of patients with AF and 8.3% of controls died. Cardiovascular diseases were the most common causes of death and the only diagnoses which showed significantly higher relative risk in patients with AF than controls (HR 2.0, 95% CI 1.8-2.3), and the relative risk was significantly higher in women than in men. Stroke was a more common cause among patients with AF, 13.1% versus 9.7% (HR 2.7, 95% CI 1.8-4.0), while cerebral hemorrhage was more common among controls, 4.7% versus 10.2% (HR 0.9, 95% CI 0.6-1.5). The time from AF diagnosis to death was 6.0 ± 3.1 years.CONCLUSIONS: In patients with incident AF and no known comorbidities at the time of AF diagnosis, only cardiovascular diseases were more often causes of death as compared to controls. Women carried a significantly higher relative risk than men.

Magnuson, AndersSchool of Medical Sciences, Örebro University, Örebro, Sweden,Clinical Epidemiology and Biostatistics,Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden. (author)
Bryngelsson, Ing-LissDepartment of Occupational and Environmental Medicine, School of Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Sch Med Sci, Dept Occupat & Environm Med, Orebro, Sweden. (author)
Frøbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Sch Med Sci, Dept Cardiol, Orebro, Sweden.(Swepub:oru)oft (author)
Henriksson, Karin M.Uppsala universitet,Kardiovaskulär epidemiologi,AstraZeneca R&D, Molndal, Sweden.(Swepub:uu)karhe322 (author)
Edvardsson, Nils,1942Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xedvni (author)
Poçi, Dritan,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology, Örebro University Hospital, Örebro, Sweden,Orebro Univ, Sch Med Sci, Dept Cardiol, Orebro, Sweden.(Swepub:oru)dnpi (author)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

By the author/editor: Andersson, Tommy ...; Magnuson, Anders; Bryngelsson, Ing ...; Frøbert, Ole, 19 ...; Henriksson, Kari ...; Edvardsson, Nils ...; show more...; Poçi, Dritan, 19 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

By the university: Örebro University; Uppsala University; University of Gothenburg

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