Placental ghrelin and leptin expression and cord blood ghrelin, adiponectin, leptin, and C-peptide levels in severe maternal obesity

Allbrand, Marianne,1958-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Obstetrics and Gynecology (author)

Funding agencies:Research Committee of Region Örebro CountyNyckelfonden, Örebro University Hospital
PURPOSE: The purpose of this study is to investigate placental ghrelin and leptin expression as well as cord blood ghrelin and adiponectin levels in maternal obesity and associations between placental ghrelin expression, cord blood ghrelin levels and maternal and infant variables.MATERIALS AND METHODS: Placental ghrelin and leptin expression were analyzed by RT-PCR in 32 severely obese and 32 matched normal-weight women. Cord blood ghrelin, adiponectin, leptin, and C-peptide concentrations were analyzed by ELISA.RESULTS: Neither ghrelin nor leptin expression and neither cord blood ghrelin nor adiponectin levels differed between the groups. Placental ghrelin expression was associated with BMI at delivery in the obese women (r = 0.424, p = .016) and in the infants born to normal-weight women with their weight z-scores at six (r = -0.642, p = .010), nine (r = -0.441, p = .015), and 12 months of age (r = -0.402, p = .028).CONCLUSIONS: Placental ghrelin and leptin expression as well as cord blood ghrelin and adiponectin levels do not seem to be altered in severe maternal obesity. Placenta-derived ghrelin may influence the infants' postnatal weight gain, but possibly only when the mother has normal weight.

Åman, Jan,1948-Department of Paediatrics, Örebro University Hospital, Örebro, Sweden (author)
Lodefalk, Maria,1968-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Health Care Research Center, Region Örebro County, Örebro, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden(Swepub:oru)malk (author)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

In:The Journal of Maternal-Fetal & Neonatal Medicine: Taylor & Francis Group31:21, s. 2839-28461476-70581476-4954

By the author/editor: Allbrand, Marian ...; Åman, Jan, 1948-; Lodefalk, Maria, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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