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Human papillomaviru...
Human papillomavirus prevalence and genotype distribution among young women and men in Maputo city, Mozambique
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- Viegas, Edna Omar (author)
- Instituto Nacional de Saúde, Maputo, Mozambique; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden; Eduardo Mondlane University, Maputo, Mozambique;
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- Augusto, Orvalho (author)
- Eduardo Mondlane University, Maputo, Mozambique
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- Ismael, Nália (author)
- Instituto Nacional de Saúde, Maputo, Mozambique
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- Kaliff, Malin, 1985- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Lillsunde-Larsson, Gabriella, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
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- Ramqvist, Torbjörn (author)
- Karolinska Institutet
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- Nilsson, Charlotta (author)
- Karolinska Institutet
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- Falk, Kerstin (author)
- Department of Microbiology, Public Health Agency of Sweden, Stockholm, Sweden; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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- Osman, Nafissa (author)
- Eduardo Mondlane University, Maputo, Mozambique; Hospital Central de Maputo, Maputo, Mozambique
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- Jani, Ilesh Vindorai (author)
- Instituto Nacional de Saúde, Maputo, Mozambique
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- Andersson, Sören, 1957- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine
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(creator_code:org_t)
- 2017-07-17
- 2017
- English.
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In: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 7:7
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Abstract
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- OBJECTIVES: Human papillomavirus (HPV) is a well-known cause of cervical cancer, the second most frequent cancer in female African populations. This study aimed at determining the prevalence of HPV infections and the genotype distribution in young adults aged 18-24, in Maputo city, Mozambique, and to assess the suitability of commercially available HPV vaccines.METHODS: This cross-sectional study was conducted between 2009 and 2011 at a youth clinic in Maputo Central Hospital. Cervical and urethral samples were obtained from 236 women and 176 men, respectively. Demographic and behavioural data were collected using structured questionnaires. HPV genotyping was performed for 35 different high, probably or possibly high-risk and low-risk HPV types using the CLART Human Papillomavirus 2.RESULTS: HPV prevalence was 168/412 (40.8%; 95% CI 36.0 to 45.5) and was significantly higher in women than in men (63.6%vs10.2%). HPV52 was the most frequent type found in women, followed by HPV35, -16,-53, -58,-6 and -51. In men, HPV51 ranked the highest, followed by HPV6, -11,-52, -59 and -70. HIV infection and sexual debut before 18 years of age were associated with multiple HPV infections (OR 3.03; 95% CI 1.49 to 6.25 and OR 6.03; 95% CI 1.73 to 21.02, respectively). Women had a significantly higher HPV infection prevalence than men (p<0.001). The 9-valent HPV vaccine would cover 36.8% of the high-risk genotypes circulating in women in this study, compared with 26.3% and 15.8% coverage by the bivalent and quadrivalent vaccines, respectively.CONCLUSION: This study confirmed the high burden of HPV infections in young women in Maputo city, Mozambique. The HPV prevalence was associated with high-risk sexual behaviour. Sex education and sexually transmitted infection prevention interventions should be intensified in Mozambique. Only a proportion of the high-risk HPV genotypes (37%) were covered by currently available vaccines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Epidemiology
- INFECTIOUS DISEASES
- Molecular diagnostics
- Public health
- SEXUAL MEDICINE
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- ref (subject category)
- art (subject category)
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Viegas, Edna Oma ...
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Augusto, Orvalho
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Ismael, Nália
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Kaliff, Malin, 1 ...
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Ramqvist, Torbjö ...
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Nilsson, Charlot ...
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Falk, Kerstin
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Osman, Nafissa
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Jani, Ilesh Vind ...
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Örebro University
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Karolinska Institutet