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The association bet...
The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity
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- La Merrill, Michele A. (author)
- Department of Environmental Toxicology, University of California, Davis, CA, USA
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- Lind, P. Monica, 1957- (author)
- Uppsala universitet,Arbets- och miljömedicin
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- Salihovic, Samira, 1985- (author)
- Uppsala universitet,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Norwegian Institute for Water Research (NIVA), Oslo, Norway,MTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden, and Norwegian Institute for Water Research, NIVA, Oslo, Norway,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden, and Norwegian Institute for Water Research, NIVA, Oslo, Norway
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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(creator_code:org_t)
- Academic Press, 2018
- 2018
- English.
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In: Environmental Research. - : Academic Press. - 0013-9351 .- 1096-0953. ; 160, s. 541-546
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- BACKGROUND AND OBJECTIVES: The pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass.METHODS: p,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques.RESULTS: We found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%).CONCLUSION: The obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Glucose
- Hypertension
- Left ventricular hypertrophy
- Obesity
- P
- p′-DDE
Publication and Content Type
- ref (subject category)
- art (subject category)
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