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The emergence of mu...
The emergence of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis patients on inhaled antibiotics
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- AbdulWahab, Atqah (author)
- Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medicine‑Qatar, Doha, Qatar
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- Zahraldin, Khalid (author)
- Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar
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- Sid Ahmed, Mazen, 1970- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Laboratory Medicine and Pathology, Microbiology Division, Hamad Medical Corporation, Doha, Qatar,Life Science Centre, Biology
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- Abu Jarir, Sulieman (author)
- Departments of Internal Medicine, Hamad Medical Corporation, Doha, Qatar
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- Muneer, Mohammed (author)
- Plastic Surgery, Hamad Medical Corporation, Doha, Qatar
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- Mohamed, Shehab F. (author)
- Departments of Internal Medicine, Hamad Medical Corporation, Doha, Qatar
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- Hamid, Jemal M. (author)
- Department of Laboratory Medicine and Pathology, Microbiology Division, Hamad Medical Corporation, Doha, Qatar
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- Hassan, Abubaker A. I. (author)
- Departments of Internal Medicine, Hamad Medical Corporation, Doha, Qatar
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- Ibrahim, Emad Bashir (author)
- Weill Cornell Medicine‑Qatar, Doha, Qatar; Department of Laboratory Medicine and Pathology, Microbiology Division, Hamad Medical Corporation, Doha, Qatar
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(creator_code:org_t)
- Medknow Publications, 2017
- 2017
- English.
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In: Lung India. - : Medknow Publications. - 0970-2113 .- 0974-598X. ; 34:6, s. 527-531
- Related links:
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https://doi.org/10.4...
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https://doi.org/10.4...
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https://urn.kb.se/re...
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Abstract
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- Introduction: Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is an important and growing issue in the care of patients with cystic fibrosis (CF), and a major cause of morbidity and mortality.Objective: The objective of the study was to describe the frequency of MDR-PA recovered from the lower respiratory samples of pediatric and adult CF patients, and its antibiotic resistance pattern to commonly used antimicrobial agents including beta-lactams, aminoglycosides, and fluoroquinolones.Materials and Methods: The lower respiratory isolates of P. aeruginosa were obtained from inpatients and outpatients CF clinics from a tertiary care teaching hospital for the period from October 2014 to September 2015. The identification and antimicrobial susceptibility for all the isolates were performed by using the BD Phoenix (TM) and E-test in compliance with Clinical and Laboratory Standards Institute (CLSI) guidelines.Results: A total of 61 P. aeruginosa samples were isolated from thirty CF patients from twenty families. Twelve sputum samples were positive for MDR-PA (seven nonmucoid and five mucoid isolates) from five CF patients (five families) with moderate-to-very severe lung disease given MDR-PA frequency of 19.7%. The median age of the study group was 20 (range 10-30) years. Three CF patients were on chronic inhaled tobramycin and two on nebulized colistin. The antimicrobial patterns of isolates MDR-PA showed the highest rate of resistance toward each gentamycin, amikacin, and cefepime (100%), followed by 91.7% to ciprofloxacin, 75% to tobramycin, 58.3% to meropenem, and 50% to piperacillin-tazobactam. None of the isolates were resistant to colistin during the study period.Conclusion: The study results emphasize that the emergence of a significant problem in the clinical isolates of P. aeruginosa in CF patients that dictate appropriate attention to the antibiotic management after proper surveillance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Cystic fibrosis
- inhaled antibiotics
- multidrug-resistant Pseudomonas aeruginosa
Publication and Content Type
- ref (subject category)
- art (subject category)
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