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Birth weight, sex, ...
Birth weight, sex, and celiac disease : a nationwide twin study
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- Kuja-Halkola, Ralf (author)
- Karolinska Institutet
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- Lebwohl, Benjamin (author)
- Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Celiac Disease Center, Columbia University Medical Center, Columbia University, New York NY, USA
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Emilsson, Louise (author)
- Department of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Oslo, Norway; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Centre for Clinical Research, Vårdcentralen Värmlands Nysäter, County Council of Värmland, Karlstad, Sweden
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- Magnusson, Patrik K. (author)
- Karolinska Institutet
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden; Dept Med, Celiac Dis Ctr, Columbia Univ, New York NY, USA; Dept Pediat, Örebro Univ Hosp, Örebro, Sweden; City Hosp, Sch Med, Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England
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(creator_code:org_t)
- DOVE Medical Press Ltd. 2017
- 2017
- English.
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In: Clinical Epidemiology. - : DOVE Medical Press Ltd.. - 1179-1349. ; 9, s. 567-577
- Related links:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Objective: Earlier research suggests that birth weight may be associated with celiac disease (CD), but the direction of association has been unclear potentially due to confounding effect from genetic and intrafamilial factors. Through within-twin analyses, we aimed to minimize confounding effects such as twins that share genetic and early environmental exposures.Materials and methods: Using the Swedish Twin Registry, we examined the birth weight of 146,830 twins according to the CD status. CD was defined as having villous atrophy according to a small intestinal biopsy reports.Results: The prevalence of diagnosed CD was 0.5% (n=669), and we included 407 discordant pairs of CD-non-CD twins. Comparing the 669 CD patients with non-CD twins, the association between birth weight and future CD was not statistically significant (odds ratio [OR] per 1000 g increase in birth weight: 1.16; 95% confidence interval [CI]=0.97-1.38). In males, the association was positive and statistically significant (OR=1.50; 95% CI=1.11-2.02). However, the association was not significant in within-pair analyses for both dizygotic and monozygotic twins and for both sexes.Conclusion: This population-based study found that in male twins, higher birth weight was associated with higher risk of CD. However, when comparing discordant twin pairs in within-twin pair analyses, there was no statistically significant association between birth weight, intrauterine growth, and future risk of CD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- autoimmune
- gestational age
- gluten
- registries
- risk factors
- twins
Publication and Content Type
- ref (subject category)
- art (subject category)
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