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  • Leblebicioglu, HakanDepartment of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University, Medical School, Samsun, Turkey (author)

Availability of hepatitis C diagnostics and therapeutics in European and Eurasia countries

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • Amsterdam, Netherlands :Elsevier,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-63296
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63296URI
  • https://doi.org/10.1016/j.antiviral.2017.12.001DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Treatment with direct acting antiviral agents (DAAs) has provided sustained virological response rates in >95% of patients with chronic hepatitis C virus (HCV) infection. However treatment is costly and market access, reimbursement and governmental restrictions differ among countries. We aimed to analyze these differences among European and Eurasian countries.METHODS: A survey including 20-item questionnaire was sent to experts in viral hepatitis. Countries were evaluated according to their income categories by the World Bank stratification.RESULTS: Experts from 26 countries responded to the survey. As of May 2016, HCV prevalence was reported as low (≤1%) in Croatia, Czech Republic, Denmark, France, Germany, Hungary, the Netherlands, Portugal, Slovenia, Spain, Sweden, UK; intermediate (1-4%) in Azerbaijan, Bosnia and Herzegovina, Italy, Kosovo, Greece, Kazakhstan, Romania, Russia, Serbia and high in Georgia (6.7%). All countries had national guidelines except Albania, Kosovo, Serbia, Tunisia, and UK. Transient elastography was available in all countries, but reimbursed in 61%. HCV-RNA was reimbursed in 81%. PegIFN/RBV was reimbursed in 54% of the countries. No DAAs were available in four countries: Kazakhstan, Kosovo, Serbia, and Tunisia. In others, at least one DAA combination with either PegIFN/RBV or another DAA was available. In Germany and the Netherlands all DAAs were reimbursed without restrictions: Sofosbuvir and sofosbuvir/ledipasvir were free of charge in Georgia.CONCLUSION: Prevalence of HCV is relatively higher in lower-middle and upper-middle income countries. DAAs are not available or reimbursed in many Eurasia and European countries. Effective screening and access to care are essential for reducing liver-related morbidity and mortality.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Arends, Joop E.Internal Medicine and Infectious Diseases, Universitair Medisch Centrum Utrecht, Utrecht, The Netherlands (author)
  • Ozaras, ResatDepartment of Infectious Diseases and Clinical Microbiology, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey (author)
  • Corti, GiampaoloInfectious Disease Unit, University of Florence School of Medicine, Florence, Italy (author)
  • Santos, LurdesInfectious Diseases Service C Hospitalar São João, Faculty of Medicine, Alameda Professor Hernani Monteiro, Porto, Portugal (author)
  • Boesecke, ChristophDepartment of Medicine I, Bonn University, Bonn, Germany (author)
  • Ustianowski, AndrewInfectious Diseases & Tropical Medicine and Research Lead, North Western Infectious Diseases Unit, Pennine Acute Hospitals NHS Trust, North Manchester General Hospital, Manchester, UK (author)
  • Duberg, Ann-Sofi,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden(Swepub:oru)adg (author)
  • Ruta, SimonaStefan S. Nicolau Institute of Virology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania (author)
  • Salkic, Nermin N.Department of Gastroenterology and Hepatology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina (author)
  • Husa, PetrInfectious Diseases, Masaryk University, Brno, Czech Republic; Infectious Diseases, University Hospital Brno, Brno, Czech Republic (author)
  • Lazarevic, IvanaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia (author)
  • Pineda, Juan A.Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain (author)
  • Pshenichnaya, Natalia YurievnaRostov State Medical University, Rostov-on-Don, Russia (author)
  • Tsertswadze, TengizInfectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi, Georgia; Faculty of Medicine, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia (author)
  • Matičič, MojcaClinic for Infectious Diseases and Febrile Illnesses, University Medical Centre, Ljubljana, Slovenia (author)
  • Puca, EdmondDepartment of Infection Diseases, University Hospital Center, Tirane, Albania (author)
  • Abuova, GulzhanInfectious Diseases Department, South - Kazakhstan State Pharmaceutical Academy, Shymkent, Kazakhstan (author)
  • Gervain, JuditDivision Hepato-Pancreatology, 1st Department of Gastroenterology and Molecular Diagnostic Laboratory, "Szent György" Teaching Hospital Székesfehérvár, Székesfehérvár, HungaryDivision Hepato-Pancreatology, 1st Department of Gastroenterology and Molecular Diagnostic Laboratory, "Szent György" Teaching Hospital Székesfehérvár, Székesfehérvár, Hungary (author)
  • Bayramli, RaminDepartment of Microbiology and Immunology, Azerbaijan Medical University, Educational Therapeutic Hospital, Baku, Azerbaijan (author)
  • Ahmeti, SalihInfectious Disease Clinic, University Clinical Centre of Kosova, Faculty of Medicine, Prishtina University, Pristina, Kosovo (author)
  • Koulentaki, MairiDepartment of Gastroenterology, University Hospital of Heraklion, Heraklion, Crete, Greece (author)
  • Kilani, BadreddineService des Maladies Infectieuses, Faculté de Médecine de Tunis, Université Tunis EL Manar, Hôpital la Rabta, Tunis, Tunisia (author)
  • Vince, AdrianaUniversity Hospital of Infectious Diseases, Zagreb School of Medicine, Zagreb, Croatia (author)
  • Negro, FrancescoDivisions of Gastroenterology and Hepatology of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland (author)
  • Sunbul, MustafaDepartment of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University, Medical School, Samsun, Turkey (author)
  • Salmon, DominiqueInfectious Diseases, Hôpitaux Universitaires Paris Centre, Université Paris Descartes, Paris, France (author)
  • Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University, Medical School, Samsun, TurkeyInternal Medicine and Infectious Diseases, Universitair Medisch Centrum Utrecht, Utrecht, The Netherlands (creator_code:org_t)

Related titles

  • In:Antiviral ResearchAmsterdam, Netherlands : Elsevier150, s. 9-140166-35421872-9096

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