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Genome-wide SNP-bas...
Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait
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- Huyghe, Jeroen R. (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Van Laer, Lut (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Hendrickx, Jan-Jaap (author)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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- Fransen, Erik (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Demeester, Kelly (author)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Topsakal, Vedat (author)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Kunst, Sylvia (author)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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- Manninen, Minna (author)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Jensen, Mona (author)
- Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
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- Bonaconsa, Amanda (author)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Mazzoli, Manuela (author)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Baur, Manuela (author)
- Department of Otorhinolaryngology, University of Tübingen, Tübingen, Germany
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- Hannula, Samuli (author)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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- Mäki-Torkko, Elina, 1961- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Hälsouniversitetet,Öronkliniken US
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- Espeso, Angeles (author)
- Welsh Hearing Institute, Cardiff University, Cardiff, UK
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- Van Eyken, Els (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Flaquer, Antonia (author)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
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- Becker, Christian (author)
- Cologne Center for Genomics (CCG) and Institute for Genetics, University of Cologne, Cologne, Germany
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- Stephens, Dafydd (author)
- Welsh Hearing Institute, Cardiff University, Cardiff, UK
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- Sorri, Martti (author)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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- Orzan, Eva (author)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Bille, Michael (author)
- Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
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- Parving, Agnete (author)
- Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
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- Pyykkö, Ilmari (author)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Cremers, Cor W. R. J. (author)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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- Kremer, Hannie (author)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, NL-6500 HB Nijmegen, the Netherlands; Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
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- Van de Heyning, Paul H. (author)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Wienker, Thomas F. (author)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
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- Nürnberg, Peter (author)
- Cologne Center for Genomics (CCG) and Institute for Genetics, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, D-50674Cologne, Germany
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- Pfister, Markus (author)
- Department of Otorhinolaryngology, University of Tübingen, Tübingen, Germany
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- Van Camp, Guy (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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(creator_code:org_t)
- Cell Press, 2008
- 2008
- English.
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In: American Journal of Human Genetics. - : Cell Press. - 0002-9297 .- 1537-6605. ; 83:3, s. 401-407
- Related links:
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Abstract
Subject headings
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- Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component analysis, we were able to reduce the dimensionality of this multivariate phenotype while capturing most of the variation and retaining biologically important features of the audiograms. We conducted a genome-wide association as well as a linkage scan with high-density SNP microarrays. Because of the presence of genetic population substructure, association testing was stratified after which evidence was combined by meta-analysis. No association signals reaching genome-wide significance were detected. Linkage analysis identified a linkage peak on 8q24.13-q24.22 for a trait correlated to audiogram shape. The signal reached genome-wide significance, as assessed by simulations. This finding represents the first locus for an ARHI trait.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Huyghe, Jeroen R ...
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Van Laer, Lut
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Hendrickx, Jan-J ...
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Fransen, Erik
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Demeester, Kelly
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Topsakal, Vedat
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show more...
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Kunst, Sylvia
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Manninen, Minna
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Jensen, Mona
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Bonaconsa, Amand ...
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Mazzoli, Manuela
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Baur, Manuela
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Hannula, Samuli
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Mäki-Torkko, Eli ...
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Espeso, Angeles
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Van Eyken, Els
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Flaquer, Antonia
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Becker, Christia ...
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Stephens, Dafydd
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Sorri, Martti
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Orzan, Eva
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Bille, Michael
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Parving, Agnete
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Pyykkö, Ilmari
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Cremers, Cor W. ...
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Kremer, Hannie
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Van de Heyning, ...
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Wienker, Thomas ...
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Nürnberg, Peter
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Pfister, Markus
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Van Camp, Guy
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Otorhinolaryngol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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American Journal ...
- By the university
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Örebro University
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Linköping University