Search: onr:"swepub:oai:DiVA.org:oru-63632" >
Genome-wide profili...
-
Elo, Laura L.Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(author)
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
- Article/chapterEnglish2010
Publisher, publication year, extent ...
-
Cell Press,2010
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:oru-63632
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63632URI
-
https://doi.org/10.1016/j.immuni.2010.06.011DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Funding agencies:European Commission EC-FP7-SYBILLA-201106 EC-FP7-NANOMMUNE-214281 EC-FP7-DIABIMMUNE-202063 CIMO/SitraSigrid Juselius FoundationDepartment of Biotechnology, Government of IndiaTurku University HospitalNote: The Turku Centre for Biotechnology is a joint department of the Turku University and the Åbo Akademi University
-
Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Järvenpää, HennaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(author)
-
Tuomela, SoileTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(author)
-
Raghav, SunilTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(author)
-
Ahlfors, HelenaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; The National Graduate School in Informational and Structural Biology, Åbo Akademi University, Turku, Finland
(author)
-
Laurila, KirstiDepartment of Signal Processing, Tampere University of Technology, Tampere, Finland
(author)
-
Gupta, BhawnaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(author)
-
Lund, Riikka J.Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Department of Biological Science, University of Sheffield, Sheffield, United Kingdom
(author)
-
Tahvanainen, JohannaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Drug Discovery Graduate School, University of Turku, Turku, Finland
(author)
-
Hawkins, R. DavidLudwig Institute for Cancer Research, University of California, San Diego CA, United States
(author)
-
Oresic, Matej,1967-VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc
(author)
-
Lähdesmäki, HarriDepartment of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Information and Computer Science, Helsinki University of Technology, Helsinki, Finland
(author)
-
Rasool, OmidTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(author)
-
Rao, Kanury V.Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland
(author)
-
Aittokallio, TeroInternational Centre for Genetic Engineering and Biotechnology, New Delhi, India; Immune Disease Institute, Harvard Medical School, Boston MA, United States
(author)
-
Lahesmaa, RiittaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Immune Disease Institute, Harvard Medical School, Boston MA, United States
(author)
-
Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, FinlandTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(creator_code:org_t)
Related titles
-
In:Immunity: Cell Press32:6, s. 852-8621074-76131097-4180
Internet link
Find in a library
-
Immunity
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Elo, Laura L.
-
Järvenpää, Henna
-
Tuomela, Soile
-
Raghav, Sunil
-
Ahlfors, Helena
-
Laurila, Kirsti
-
show more...
-
Gupta, Bhawna
-
Lund, Riikka J.
-
Tahvanainen, Joh ...
-
Hawkins, R. Davi ...
-
Oresic, Matej, 1 ...
-
Lähdesmäki, Harr ...
-
Rasool, Omid
-
Rao, Kanury V.
-
Aittokallio, Ter ...
-
Lahesmaa, Riitta
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
- Articles in the publication
-
Immunity
- By the university
-
Örebro University