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  • Elo, Laura L.Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland (author)

Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • Cell Press,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-63632
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63632URI
  • https://doi.org/10.1016/j.immuni.2010.06.011DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:European Commission EC-FP7-SYBILLA-201106 EC-FP7-NANOMMUNE-214281 EC-FP7-DIABIMMUNE-202063 CIMO/SitraSigrid Juselius FoundationDepartment of Biotechnology, Government of IndiaTurku University HospitalNote:  The Turku Centre for Biotechnology is a joint department of the Turku University and the Åbo Akademi University
  • Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Järvenpää, HennaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland (author)
  • Tuomela, SoileTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland (author)
  • Raghav, SunilTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland (author)
  • Ahlfors, HelenaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; The National Graduate School in Informational and Structural Biology, Åbo Akademi University, Turku, Finland (author)
  • Laurila, KirstiDepartment of Signal Processing, Tampere University of Technology, Tampere, Finland (author)
  • Gupta, BhawnaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland (author)
  • Lund, Riikka J.Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Department of Biological Science, University of Sheffield, Sheffield, United Kingdom (author)
  • Tahvanainen, JohannaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Drug Discovery Graduate School, University of Turku, Turku, Finland (author)
  • Hawkins, R. DavidLudwig Institute for Cancer Research, University of California, San Diego CA, United States (author)
  • Oresic, Matej,1967-VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc (author)
  • Lähdesmäki, HarriDepartment of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Information and Computer Science, Helsinki University of Technology, Helsinki, Finland (author)
  • Rasool, OmidTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland (author)
  • Rao, Kanury V.Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland (author)
  • Aittokallio, TeroInternational Centre for Genetic Engineering and Biotechnology, New Delhi, India; Immune Disease Institute, Harvard Medical School, Boston MA, United States (author)
  • Lahesmaa, RiittaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Immune Disease Institute, Harvard Medical School, Boston MA, United States (author)
  • Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, FinlandTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland (creator_code:org_t)

Related titles

  • In:Immunity: Cell Press32:6, s. 852-8621074-76131097-4180

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