Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo

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Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo

Virtue, Sam (author): Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Masoodi, Mojgan (author): Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, Cambridge, United Kingdom

Velagapudi, Vidya (author): VTT Technical Research Centre of Finland, Espoo, Finland

Tan, Chong Yew (author): Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Dale, Martin (author): University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom

Suorti, Tapani (author): VTT Technical Research Centre of Finland, Espoo, Finland

Slawik, Marc (author): Department of Medicine Innenstadt, Endocrinology/Diabetes University Hospital, Munich, Germany

Blount, Margaret (author): University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom

Burling, Keith (author): University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom

Campbell, Mark (author): University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom

Eguchi, Naomi (author): Osaka Bioscience Institute, Osaka, Japan

Medina-Gomez, Gema (author): Departamento de Bioquímica, Fisiología y Genética Molecular, Universidad Rey Juan Carlos, Madrid, Spain

Sethi, Jaswinder K (author): University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom

Oresic, Matej, 1967- (author): Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland

Urade, Yoshihiro (author): Osaka Bioscience Institute, Osaka, Japan

Griffin, Julian L (author): Department of Biochemistry, Medical Research Council Human Nutrition Research, Cambridge, United Kingdom

Vidal-Puig, Antonio (author): University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom

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2012-07-05
2012
English.
In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7

Related links:: https://doi.org/10.1...; show more...; https://journals.plo...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

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Mice lacking Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) have unexpectedly normal glucose tolerance and mild insulin resistance. Mice lacking PPARγ2 were found to have elevated levels of Lipocalin prostaglandin D synthase (L-PGDS) expression in BAT and subcutaneous white adipose tissue (WAT). To determine if induction of L-PGDS was compensating for a lack of PPARγ2, we crossed L-PGDS KO mice to PPARγ2 KO mice to generate Double Knock Out mice (DKO). Using DKO mice we demonstrated a requirement of L-PGDS for maintenance of subcutaneous WAT (scWAT) function. In scWAT, DKO mice had reduced expression of thermogenic genes, the de novo lipogenic program and the lipases ATGL and HSL. Despite the reduction in markers of lipolysis in scWAT, DKO mice had a normal metabolic rate and elevated serum FFA levels compared to L-PGDS KO alone. Analysis of intra-abdominal white adipose tissue (epididymal WAT) showed elevated expression of mRNA and protein markers of lipolysis in DKO mice, suggesting that DKO mice may become more reliant on intra-abdominal WAT to supply lipid for oxidation. This switch in depot utilisation from subcutaneous to epididymal white adipose tissue was associated with a worsening of whole organism metabolic function, with DKO mice being glucose intolerant, and having elevated serum triglyceride levels compared to any other genotype. Overall, L-PGDS and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism.

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By the author/editor: Virtue, Sam; Masoodi, Mojgan; Velagapudi, Vidy ...; Tan, Chong Yew; Dale, Martin; Suorti, Tapani; show more...; Slawik, Marc; Blount, Margaret; Burling, Keith; Campbell, Mark; Eguchi, Naomi; Medina-Gomez, Ge ...; Sethi, Jaswinder ...; Oresic, Matej, 1 ...; Urade, Yoshihiro; Griffin, Julian ...; Vidal-Puig, Anto ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: PLOS ONE

By the university: Örebro University

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Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo

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