Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes

Oresic, Matej, 1967- (author): Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland

Gopalacharyulu, Peddinti (author): VTT Technical Research Centre of Finland, Espoo, Finland

Mykkänen, Juha (author): Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland

Lietzen, Niina (author): VTT Technical Research Centre of Finland, Espoo, Finland

Mäkinen, Marjaana (author): Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland

Nygren, Heli (author): VTT Technical Research Centre of Finland, Espoo, Finland

Simell, Satu (author): Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland

Simell, Ville (author): Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland

Hyöty, Heikki (author): Department of Virology, School of Medicine, University of Tampere, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland

Veijola, Riitta (author): Institute of Clinical Medicine, University of Oulu, Oulu, Finland

Ilonen, Jorma (author): Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland; Immunogenetics Laboratory, University of Turku, Turku, Finland

Sysi-Aho, Marko (author): VTT Technical Research Centre of Finland, Espoo, Finland

Knip, Mikael (author): Children’s Hospital, University of Helsinki, Helsinki, Finland; Helsinki University Central Hospital, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland

Hyötyläinen, Tuulia, 1971- (author): Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland

Simell, Olli (author): Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland

(creator_code:org_t)

2013-08-15
2013
English.
In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 62:9, s. 3268-3274

Related links:: https://doi.org/10.2...; show more...; https://diabetes.dia...; https://urn.kb.se/re...; https://doi.org/10.2...; show less...

Abstract Subject headings

Previous studies show that children who later progress to type 1 diabetes (T1D) have decreased preautoimmune concentrations of multiple phospholipids as compared with nonprogressors. It is still unclear whether these changes associate with development of β-cell autoimmunity or specifically with clinical T1D. Here, we studied umbilical cord serum lipidome in infants who later developed T1D (N = 33); infants who developed three or four (N = 31) islet autoantibodies, two (N = 31) islet autoantibodies, or one (N = 48) islet autoantibody during the follow-up; and controls (N = 143) matched for sex, HLA-DQB1 genotype, city of birth, and period of birth. The analyses of serum molecular lipids were performed using the established lipidomics platform based on ultra-performance liquid chromatography coupled to mass spectrometry. We found that T1D progressors are characterized by a distinct cord blood lipidomic profile that includes reduced major choline-containing phospholipids, including sphingomyelins and phosphatidylcholines. A molecular signature was developed comprising seven lipids that predicted high risk for progression to T1D with an odds ratio of 5.94 (95% CI, 1.07-17.50). Reduction in choline-containing phospholipids in cord blood therefore is specifically associated with progression to T1D but not with development of β-cell autoimmunity in general.

By the author/editor: Oresic, Matej, 1 ...; Gopalacharyulu, ...; Mykkänen, Juha; Lietzen, Niina; Mäkinen, Marjaan ...; Nygren, Heli; show more...; Simell, Satu; Simell, Ville; Hyöty, Heikki; Veijola, Riitta; Ilonen, Jorma; Sysi-Aho, Marko; Knip, Mikael; Hyötyläinen, Tuu ...; Simell, Olli; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.