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Search: onr:"swepub:oai:DiVA.org:oru-63703" > The dynamics of the...

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  • Kostic, Aleksandar D.Broad Institute of MIT and Harvard, Cambridge MA, United States; Center for Computational and Integrative Bioogy, Massachusetts General Hospital, Harvard Medical School, Boston MA, United States; Department of Biostatistics, Harvard School of Public Health, Boston MA, United States (author)

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Cell Press,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-63703
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63703URI
  • https://doi.org/10.1016/j.chom.2015.01.001DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:European Union 202063 Juvenile Diabetes Research Foundation 17-2011-529 17-2014-305 Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research 250114 National Institutes of Health P30 DK043351 U54 DK102557
  • Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genetically predisposed to T1D. Modeling trajectories of microbial abundances through infancy revealed a subset of microbial relationships shared across most subjects. Although strain composition of a given species was highly variable between individuals, it was stable within individuals throughout infancy. Metabolic composition and metabolic pathway abundance remained constant across time. A marked drop in alpha-diversity was observed in T1D progressors in the time window between seroconversion and T1D diagnosis, accompanied by spikes in inflammation-favoring organisms, gene functions, and serum and stool metabolites. This work identifies trends in the development of the human infant gut microbiome along with specific alterations that precede T1D onset and distinguish T1D progressors from nonprogressors.

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  • Gevers, DirkBroad Institute of MIT and Harvard, Cambridge MA, United States (author)
  • Siljander, HeliDepartment of Biostatistics, Harvard School of Public Health, Boston MA, United States; Children's Hospital, University of Helsinki, Helsinki University Hospital, Helsinki, Finland (author)
  • Vatanen, TommiBroad Institute of MIT and Harvard, Cambridge MA, United States; Department of Information and Computer Science, Aalto University School of Science, Espoo, Finland (author)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Steno Diabetes Center, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn (author)
  • Hämäläinen, Anu-MaariaDepartment of Pediatrics, Jorvi Hospital, Espoo, Finland (author)
  • Peet, AleksandrDepartment of Pediatrics, University of Tartu, Estonia and Tartu University Hospital, Tartu, Estonia (author)
  • Tillmann, ValloDepartment of Pediatrics, University of Tartu, Estonia and Tartu University Hospital, Tartu, Estonia (author)
  • Pöhö, PäiviFaculty of Pharmacy, University of Helsinki, Helsinki, Finland; VTT Technical Research Centre of Finland, Espoo, Finland (author)
  • Mattila, IsmoSteno Diabetes Center, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland (author)
  • Lähdesmäki, Harri (author)
  • Franzosa, Eric A.Department of Biostatistics, Harvard School of Public Health, Boston MA, United States (author)
  • Vaarala, OutiResearch Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland (author)
  • de Goffau, MarcusDepartment of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (author)
  • Harmsen, HermieDepartment of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (author)
  • Ilonen, JormaImmunogenetics Laboratory, University of Turku, Turku, Finland; Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland (author)
  • Virtanen, Suvi M.Department of Lifestyle and Participation, National Institute for Health and Welfare, Helsinki, Finland; School of Health Sciences, University of Tampere, Tampere, Finland; Science Centre, Pirkanmaa Hospital District, Tampere, Finland (author)
  • Clish, Clary B.Broad Institute of MIT and Harvard, Cambridge MA, United States (author)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Broad Institute of MIT and Harvard, Cambridge MA, United States; VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc (author)
  • Huttenhower, CurtisBroad Institute of MIT and Harvard, Cambridge MA, United States; Department of Biostatistics, Harvard School of Public Health, Boston MA, United States (author)
  • Knip, MikaelChildren's Hospital, University of Helsinki, Helsinki University Hospital, Helsinki, Finland; Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland (author)
  • Xavier, Ramnik J.Broad Institute of MIT and Harvard, Cambridge MA, United States; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston MA, United States; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, United States; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge MA, United States (author)
  • Broad Institute of MIT and Harvard, Cambridge MA, United States; Center for Computational and Integrative Bioogy, Massachusetts General Hospital, Harvard Medical School, Boston MA, United States; Department of Biostatistics, Harvard School of Public Health, Boston MA, United StatesBroad Institute of MIT and Harvard, Cambridge MA, United States (creator_code:org_t)

Related titles

  • In:Cell Host and Microbe: Cell Press17:2, s. 260-2731931-31281934-6069

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