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Metabolomics of hum...
Metabolomics of human breast cancer : new approaches for tumor typing and biomarker discovery
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- Denkert, Carsten (author)
- Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany
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- Bucher, Elmar (author)
- Biotechnology for Health and Well-being, VTT Technical Research Centre of Finland, Espoo and Turku, Finland
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- Hilvo, Mika (author)
- Biotechnology for Health and Well-being, VTT Technical Research Centre of Finland, Espoo and Turku, Finland
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- Salek, Reza (author)
- Department of Biochemistry, University of Cambridge, Cambridge, UK
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- Oresic, Matej, 1967- (author)
- Biotechnology for Health and Well-being, VTT Technical Research Centre of Finland, Espoo and Turku, Finland
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- Griffin, Julian (author)
- Department of Biochemistry, University of Cambridge, Cambridge, UK
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- Brockmöller, Scarlet (author)
- Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany
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- Klauschen, Frederick (author)
- Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany
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- Loibl, Sibylle (author)
- German Breast Group, GBG-Forschungs GmbH, Neu-Isenburg, Germany
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- Barupal, Dinesh Kumar (author)
- Genome Center, University of California, Davis CA, USA
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- Budczies, Jan (author)
- Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany
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- Iljin, Kristiina (author)
- Biotechnology for Health and Well-being, VTT Technical Research Centre of Finland, Espoo and Turku, Finland
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- Nekljudova, Valentina (author)
- German Breast Group, GBG-Forschungs GmbH, Neu-Isenburg, Germany
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- Fiehn, Oliver (author)
- Genome Center, University of California, Davis CA, USA
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(creator_code:org_t)
- 2012-04-30
- 2012
- English.
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In: Genome Medicine. - London, United Kingdom : BioMed Central (BMC). - 1756-994X. ; 4:4
- Related links:
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https://genomemedici...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Breast cancer is the most common cancer in women worldwide, and the development of new technologies for better understanding of the molecular changes involved in breast cancer progression is essential. Metabolic changes precede overt phenotypic changes, because cellular regulation ultimately affects the use of small-molecule substrates for cell division, growth or environmental changes such as hypoxia. Differences in metabolism between normal cells and cancer cells have been identified. Because small alterations in enzyme concentrations or activities can cause large changes in overall metabolite levels, the metabolome can be regarded as the amplified output of a biological system. The metabolome coverage in human breast cancer tissues can be maximized by combining different technologies for metabolic profiling. Researchers are investigating alterations in the steady state concentrations of metabolites that reflect amplified changes in genetic control of metabolism. Metabolomic results can be used to classify breast cancer on the basis of tumor biology, to identify new prognostic and predictive markers and to discover new targets for future therapeutic interventions. Here, we examine recent results, including those from the European FP7 project METAcancer consortium, that show that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights. We predict an intensified use of metabolomic screens in clinical and preclinical studies focusing on the onset and progression of tumor development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast cancer
- metabolomics
- lipidomics
- biomarker analysis
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- ref (subject category)
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- By the author/editor
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Denkert, Carsten
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Bucher, Elmar
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Hilvo, Mika
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Salek, Reza
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Oresic, Matej, 1 ...
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Griffin, Julian
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Brockmöller, Sca ...
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Klauschen, Frede ...
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Loibl, Sibylle
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Barupal, Dinesh ...
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Budczies, Jan
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Iljin, Kristiina
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Nekljudova, Vale ...
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Fiehn, Oliver
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Genome Medicine
- By the university
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Örebro University