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Extracellular-regul...
Extracellular-regulated protein kinase cascades are activated in response to injury in human skeletal muscle
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- Aronson, D. (author)
- Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
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- Wojtaszewski, J. (author)
- Copenhagen Muscle Research Center, August Krogh Institute, University of Copenhagen, Copenhagen, Denmark
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- Thorell, A. (author)
- Karolinska Institutet
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- Nygren, J. (author)
- Karolinska Institutet
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- Zangen, A. (author)
- Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
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- Richter, E. A. (author)
- Copenhagen Muscle Research Center, August Krogh Institute, University of Copenhagen, Copenhagen, Denmark
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- Ljungqvist, Olle, 1954- (author)
- Karolinska Institutet
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- Fielding, R. A. (author)
- Department of Health Sciences, Sargent Coll. All. Hlth. Professions, Boston University, Boston, MA , United States
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- Goodyear, L. J. (author)
- Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; Joslin Diabetes Center, One Joslin Place, Boston, MA, United States
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Zangen, D (author)
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(creator_code:org_t)
- HighWire Press, 1998
- 1998
- English.
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In: American Journal of Physiology. - : HighWire Press. - 0002-9513 .- 2163-5773. ; 275:2, s. C555-C561
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The mitogen-activated protein (MAP) kinase signaling pathways are believed to act as critical signal transducers between stress stimuli and transcriptional responses in mammalian cells. However, it is not known whether these signaling cascades also participate in the response to injury in human tissues. To determine whether injury to the vastus lateralis muscle activates MAP kinase signaling in human subjects, two needle biopsies or open muscle biopsies were taken from the same incision site 30-60 min apart. The muscle biopsy procedures resulted in striking increases in dual phosphorylation of the extracellular-regulated kinases (ERK1 and ERK2) and in activity of the downstream substrate, the p90 ribosomal S6 kinase. Raf-1 kinase and MAP kinase kinase, upstream activators of ERK, were also markedly stimulated in all subjects. In addition, c-Jun NH2-terminal kinase and p38 kinase, components of two parallel MAP kinase pathways, were activated following muscle injury. The stimulation of the three MAP kinase cascades was present only in the immediate vicinity of the injury, a finding consistent with a local rather than systemic activation of these signaling cascades in response to injury. These data demonstrate that muscle injury induces the stimulation of the three MAP kinase cascades in human skeletal muscle, suggesting a physiological relevance of these protein kinases in the immediate response to tissue injury and possibly in the initiation of wound healing.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Mitogen-activated protein kinase
- signal transduction
- stress enzymology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Aronson, D.
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Wojtaszewski, J.
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Thorell, A.
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Nygren, J.
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Zangen, A.
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Richter, E. A.
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show more...
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Ljungqvist, Olle ...
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Fielding, R. A.
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Goodyear, L. J.
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Zangen, D
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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American Journal ...
- By the university
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Örebro University
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Karolinska Institutet