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  • Naukkarinen, J.Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Biomedicum Helsinki, Finland; FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland (author)

Characterising metabolically healthy obesity in weight-discordant monozygotic twins

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2013-10-08
  • New York, USA :Springer,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-65686
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-65686URI
  • https://doi.org/10.1007/s00125-013-3066-yDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cited By :56; Export Date: 12 March 2018; ArticleFunding Agencies:Helsinki University Central HospitalBiomedicum HelsinkiJalmari and Rauha Ahokas (KHP)Finnish Medical Foundations Finnish Foundation for Cardiovascular Research Competitive Research Funding of the Pirkanmaa Hospital DistrictAcademy of Finland Centre of Excellence in Complex Disease GeneticsNational Institute of Alcohol Abuse and Alcoholism 
  • Aims/hypothesis: Not all obese individuals display the metabolic disturbances commonly associated with excess fat accumulation. Mechanisms maintaining this ‘metabolically healthy obesity’ (MHO) are as yet unknown. We aimed to study different fat depots and transcriptional pathways in subcutaneous adipose tissue (SAT) as related to the MHO phenomenon.Methods: Sixteen rare young adult obesity-discordant monozygotic (MZ) twin pairs (intra-pair difference (∆) in BMI ≥3 kg/m2), aged 22.8–35.8 years, were examined for detailed characteristics of metabolic health (subcutaneous, intra-abdominal and liver fat [magnetic resonance imaging/spectroscopy]), OGTT, lipids, adipokines and C-reactive protein (CRP). Affymetrix U133 Plus 2.0 chips were used to analyse transcriptomics pathways related to mitochondrial function and inflammation in SAT.Results: Based on liver fat accumulation, two metabolically different subgroups emerged. In half (8/16) of the pairs (∆weight 17.1 ± 2.0 kg), the obese co-twin had significantly higher liver fat (∆718%), 78% increase in AUC insulin during OGTT and CRP, significantly more disturbance in the lipid profile and greater tendency for hypertension compared with the lean co-twin. In these obese co-twins, SAT expression of mitochondrial oxidative phosphorylation, branched-chain amino acid catabolism, fatty acid oxidation and adipocyte differentiation pathways were downregulated and chronic inflammation upregulated. In the other eight pairs (∆weight 17.4 ± 2.8 kg), the obese co-twin did not differ from the non-obese co-twin in liver fat (∆8%), insulin sensitivity, CRP, lipids, blood pressure or SAT transcriptomics.Conclusions/interpretation: Our results suggest that maintenance of high mitochondrial transcription and lack of inflammation in SAT are associated with low liver fat and MHO.

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  • Heinonen, S.Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Biomedicum Helsinki, Finland (author)
  • Hakkarainen, A.Helsinki Medical Imaging Center, University of Helsinki, Helsinki, Finland (author)
  • Lundbom, J.Helsinki Medical Imaging Center, University of Helsinki, Helsinki, Finland (author)
  • Vuolteenaho, K.The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland (author)
  • Saarinen, L.Computational Systems Biology Laboratory, Genome-Scale Biology Research Program, Institute of Biomedicine, University of Helsinki, Helsinki, Finland (author)
  • Hautaniemi, S.Computational Systems Biology Laboratory, Genome-Scale Biology Research Program, Institute of Biomedicine, University of Helsinki, Helsinki, Finland (author)
  • Rodriguez, A.Metabolic Research Laboratory, Clinica Univ. de Navarra, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain (author)
  • Frühbeck, G.Metabolic Research Laboratory, Clinica Univ. de Navarra, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain (author)
  • Pajunen, P.Diabetes Prevention Unit,Division of Welfare andHealth Promotion, National Institute for Health and Welfare, Helsinki, Finland (author)
  • Hyötyläinen, Tuulia,1971-Systems Biology and Bioinformatics, VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn (author)
  • Oresic, Matej,1967-Systems Biology and Bioinformatics, VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc (author)
  • Moilanen, E.The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland (author)
  • Suomalainen, A.Research Program of Molecular Neurology and Department of Neurology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (author)
  • Lundbom, N.Helsinki Medical Imaging Center, University of Helsinki, Helsinki, Finland (author)
  • Kaprio, J.FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Finnish Twin Cohort Study, Hjelt Institute, University of Helsinki, Helsinki, Finland; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland (author)
  • Rissanen, A.Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Biomedicum Helsinki, Finland (author)
  • Pietiläinen, K. H.Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Biomedicum Helsinki, Finland; FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland (author)
  • Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Biomedicum Helsinki, Finland; FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, FinlandObesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Biomedicum Helsinki, Finland (creator_code:org_t)

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  • In:DiabetologiaNew York, USA : Springer57:1, s. 167-1760012-186X1432-0428

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