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Efficacy of succime...
Efficacy of succimer chelation of mercury at background exposures in toddlers : a randomized trial
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- Cao, Yang, Associate Professor, 1972- (author)
- Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Department of Health Statistics, Faculty of Health Services, Second Military Medical University, Shanghai, China
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- Chen, Aimin (author)
- Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
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- Jones, Robert L. (author)
- Inorganic and Radiation Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
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- Radcliffe, Jerilynn (author)
- The Children’s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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- Dietrich, Kim N. (author)
- Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
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- Caldwell, Kathleen L. (author)
- Inorganic and Radiation Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
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- Peddada, Shyamal (author)
- Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, USA
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- Rogan, Walter J (author)
- Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
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(creator_code:org_t)
- Elsevier, 2011
- 2011
- English.
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In: The Journal of Pediatrics. - : Elsevier. - 0022-3476 .- 1097-6833. ; 158:3, s. 480-485.e1
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Abstract
Subject headings
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- OBJECTIVE: To examine whether succimer, a mercaptan compound known to reduce blood lead concentration in children, reduces blood mercury concentration.STUDY DESIGN: We used samples from a randomized clinical trial of succimer chelation for lead-exposed children. We measured mercury levels in pre-treatment samples from 767 children. We also measured mercury levels in blood samples drawn 1 week after treatment began (n = 768) and in a 20% random sample of the children who received the maximum 3 courses of treatment (n = 67). A bootstrap-based isotonic regression method was used to compare the trend with time in the difference between the adjusted mean mercury concentrations in the succimer group and that in the placebo group.RESULTS: The adjusted mean organic mercury concentration in the succimer group relative to the placebo group fell from 99% at baseline to 82% after 3 courses of treatment (P for trend = .048), but this resulted from the prevention of the age-related increase in the succimer group.CONCLUSION: Succimer chelation for low level organic mercury exposure in children has limited efficacy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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