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Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion : inconclusive results

Ingberg, Edvin, 1988- (author)
Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Orebro Univ, Sweden
Dock, Hua (author)
Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
Theodorsson, Elvar (author)
Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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Theodorsson, Annette (author)
Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurokirurgiska kliniken US
Ström, Jakob O., 1983- (author)
Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; Department of Neurology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi,Orebro Univ, Sweden
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 (creator_code:org_t)
2018-04-19
2018
English.
In: BMC Neuroscience. - London : BioMed Central. - 1471-2202. ; 19:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: Stroke is among the leading causes of death and disability. Although intense research efforts have provided promising treatment options in animals, most clinical trials in humans have failed and the therapeutic options are few. Several factors have been suggested to explain this translational difficulty, particularly concerning methodology and study design. Consistent infarcts and low mortality might be desirable in some, but not all, studies. Here, we aimed to investigate whether the use of laser Doppler flowmetry (LDF) and the occlusion time (60 vs. 45 min) affected outcome variability and mortality in a rat stroke model. Eighty ovariectomized female Wistar rats were subjected to ischemic stroke using intraluminal filament middle cerebral artery occlusion with or without LDF and with occlusion times of 45 or 60 min. Outcome was evaluated by triphenyl tetrazolium chloride staining of brain slices to measure infarct size and a modified sticky tape test.RESULTS: Neither LDF nor occlusion times of 45 versus 60 min significantly affected mortality, outcome variability or outcome severity.CONCLUSIONS: Due to the unexpectedly high mortality and variability the statistical power was very low and thus the results were inconclusive.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

Rats
Middle cerebral artery occlusion
Ischemic stroke
Laser Doppler flowmetry
Mortality
Variability

Publication and Content Type

ref (subject category)
art (subject category)

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