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  • Alhamdow, AymanKarolinska Institute,Karolinska Institutet (author)

DNA-methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-05-02
  • Oxford University Press,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-67021
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67021URI
  • https://doi.org/10.1093/carcin/bgy059DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138705454URI
  • https://lup.lub.lu.se/record/a6d9bd1a-d0d8-4d4e-976f-64bb8f9b1292URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agency:Medical Training and Research Agreement (ALF grants; Region Örebro län)  OLL-550721
  • Some polycyclic aromatic hydrocarbons (PAH) are known carcinogens and workplace PAH exposure may increase the risk of cancer. Monitoring early cancer-related changes can indicate whether the exposure is carcinogenic. Here, we enrolled 151 chimney sweeps, 152 controls, and 19 creosote-exposed male workers from Sweden. We measured urinary PAH metabolites using LC/MS/MS, the cancer-related markers telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) using qPCR, and DNA methylation of lung cancer-related genes F2RL3 and AHRR using pyrosequencing. The median 1-hydroxypyrene (PAH metabolite) concentrations were highest in creosote-exposed workers (8.0 μg/g creatinine) followed by chimney sweeps (0.34 μg/g creatinine) and controls (0.05 μg/g creatinine). TL and mtDNAcn did not differ between study groups. Chimney sweeps and creosote-exposed workers had significantly lower methylation of AHRR CpG site cg05575921 (88.1% and 84.9%, respectively) than controls (90%). Creosote-exposed workers (73.3%), but not chimney sweeps (76.6%) had lower methylation of F2RL3 cg03636183 than controls (76.7%). Linear regression analyses showed that chimney sweeps had lower AHRR cg05575921 methylation (B=-2.04; P<0.057, adjusted for smoking and age) and lower average AHRR methylation (B=-2.05; P<0.035), and non-smoking chimney sweeps had lower average F2RL3 methylation (B=-0.81; P<0.042, adjusted for age) compared with controls. These cancer-related markers were not associated with urinary concentrations of PAH metabolites. In conclusion, although we found no associations with PAH metabolites in urine (short-term exposure), our results suggest dose-response relationship between PAH exposure and DNA hypomethylation of lung cancer-related loci. These findings indicate that further protective measures should be taken to reduce PAH exposure.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lindh, ChristianLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-cli (author)
  • Hagberg, Jessika,1974-Örebro University,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,MTM Research Centre(Swepub:oru)jahg (author)
  • Graff, Pål,1973-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; National Institute of Occupational Health, Oslo, Norway(Swepub:oru)pgf (author)
  • Westberg, Håkan,1949-Örebro University,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,MTM Research Centre(Swepub:oru)hwg (author)
  • Krais, Annette MLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)med-ak5 (author)
  • Albin, MariaLund University,Lunds universitet,Stockholm County Council,Karolinska Institute,Karolinska Institutet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Arbetsorganisation och hälsa,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Environmental health and occupational health,Lund University Research Groups(Swepub:lu)ymed-mal (author)
  • Gustavsson, PerKarolinska Institutet (author)
  • Tinnerberg, HåkanLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-hti (author)
  • Broberg, KarinKarolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-kbr (author)
  • Karolinska InstituteKarolinska Institutet (creator_code:org_t)

Related titles

  • In:Carcinogenesis: Oxford University Press39:7, s. 869-8780143-33341460-2180

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