Search: onr:"swepub:oai:DiVA.org:oru-67021" > DNA-methylation of ...
Fältnamn | Indikatorer | Metadata |
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000 | 07403naa a2200541 4500 | |
001 | oai:DiVA.org:oru-67021 | |
003 | SwePub | |
008 | 180604s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:138705454 | |
009 | oai:lup.lub.lu.se:a6d9bd1a-d0d8-4d4e-976f-64bb8f9b1292 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-670212 URI |
024 | 7 | a https://doi.org/10.1093/carcin/bgy0592 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1387054542 URI |
024 | 7 | a https://lup.lub.lu.se/record/a6d9bd1a-d0d8-4d4e-976f-64bb8f9b12922 URI |
040 | a (SwePub)orud (SwePub)kid (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Alhamdow, Aymanu Karolinska Institute,Karolinska Institutet4 aut0 (Swepub:lu)med-aa10 |
245 | 1 0 | a DNA-methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons |
264 | c 2018-05-02 | |
264 | 1 | b Oxford University Press,c 2018 |
338 | a print2 rdacarrier | |
500 | a Funding Agency:Medical Training and Research Agreement (ALF grants; Region Örebro län) OLL-550721 | |
520 | a Some polycyclic aromatic hydrocarbons (PAH) are known carcinogens and workplace PAH exposure may increase the risk of cancer. Monitoring early cancer-related changes can indicate whether the exposure is carcinogenic. Here, we enrolled 151 chimney sweeps, 152 controls, and 19 creosote-exposed male workers from Sweden. We measured urinary PAH metabolites using LC/MS/MS, the cancer-related markers telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) using qPCR, and DNA methylation of lung cancer-related genes F2RL3 and AHRR using pyrosequencing. The median 1-hydroxypyrene (PAH metabolite) concentrations were highest in creosote-exposed workers (8.0 μg/g creatinine) followed by chimney sweeps (0.34 μg/g creatinine) and controls (0.05 μg/g creatinine). TL and mtDNAcn did not differ between study groups. Chimney sweeps and creosote-exposed workers had significantly lower methylation of AHRR CpG site cg05575921 (88.1% and 84.9%, respectively) than controls (90%). Creosote-exposed workers (73.3%), but not chimney sweeps (76.6%) had lower methylation of F2RL3 cg03636183 than controls (76.7%). Linear regression analyses showed that chimney sweeps had lower AHRR cg05575921 methylation (B=-2.04; P<0.057, adjusted for smoking and age) and lower average AHRR methylation (B=-2.05; P<0.035), and non-smoking chimney sweeps had lower average F2RL3 methylation (B=-0.81; P<0.042, adjusted for age) compared with controls. These cancer-related markers were not associated with urinary concentrations of PAH metabolites. In conclusion, although we found no associations with PAH metabolites in urine (short-term exposure), our results suggest dose-response relationship between PAH exposure and DNA hypomethylation of lung cancer-related loci. These findings indicate that further protective measures should be taken to reduce PAH exposure. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Lindh, Christianu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups4 aut0 (Swepub:lu)ymed-cli |
700 | 1 | a Hagberg, Jessika,d 1974-u Örebro University,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,MTM Research Centre4 aut0 (Swepub:oru)jahg |
700 | 1 | a Graff, Pål,d 1973-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; National Institute of Occupational Health, Oslo, Norway4 aut0 (Swepub:oru)pgf |
700 | 1 | a Westberg, Håkan,d 1949-u Örebro University,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,MTM Research Centre4 aut0 (Swepub:oru)hwg |
700 | 1 | a Krais, Annette Mu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups4 aut0 (Swepub:lu)med-ak5 |
700 | 1 | a Albin, Mariau Lund University,Lunds universitet,Stockholm County Council,Karolinska Institute,Karolinska Institutet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Arbetsorganisation och hälsa,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Environmental health and occupational health,Lund University Research Groups4 aut0 (Swepub:lu)ymed-mal |
700 | 1 | a Gustavsson, Peru Karolinska Institutet4 aut |
700 | 1 | a Tinnerberg, Håkanu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-hti |
700 | 1 | a Broberg, Karinu Karolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-kbr |
710 | 2 | a Karolinska Instituteb Karolinska Institutet4 org |
773 | 0 | t Carcinogenesisd : Oxford University Pressg 39:7, s. 869-878q 39:7<869-878x 0143-3334x 1460-2180 |
856 | 4 | u https://doi.org/10.1093/carcin/bgy059y Fulltext |
856 | 4 | u https://academic.oup.com/carcin/article-pdf/39/7/869/25121411/bgy059.pdf |
856 | 4 | u http://dx.doi.org/10.1093/carcin/bgy059x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67021 |
856 | 4 8 | u https://doi.org/10.1093/carcin/bgy059 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138705454 |
856 | 4 8 | u https://lup.lub.lu.se/record/a6d9bd1a-d0d8-4d4e-976f-64bb8f9b1292 |
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