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Comparison between ...
Comparison between professional sampling and self-sampling for HPV-based cervical cancer screening among postmenopausal women
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- Bergengren, Lovisa, 1971- (author)
- Örebro universitet,Institutionen för hälsovetenskaper,Department of Women’s Health
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- Kaliff, Malin, 1985- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine
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- Lillsunde-Larsson, Gabriella, 1971- (author)
- Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine
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- Karlsson, Mats, 1960- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine
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- Helenius, Gisela, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine
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(creator_code:org_t)
- 2018-06-25
- 2018
- English.
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In: International Journal of Gynecology & Obstetrics. - : Wiley-Blackwell Publishing Inc.. - 0020-7292 .- 1879-3479. ; 142:3, s. 359-364
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVE: To investigate whether self-sampling is as reliable as professional sampling for HPV testing and genotype detection among postmenopausal women.METHODS: In the present prospective cross-sectional study, women in Örebro County, Sweden, who had high-risk HPV (hrHPV) and normal cytology results in exit screening tests conducted in between January 1, 2012, and December 31, 2014, were invited to follow-up screenings between February 24, 2015 and May 15, 2015, that included professional sampling and self-sampling. HPV genotypes were identified by a DNA-based assay that could detect 35 HPV genotypes. Findings between the different sampling methods were compared.RESULTS: Of 143 women who participated, 119 returned a self-sample. Completely concordant results were observed in 67 of these samples when both hrHPV and low-risk HPV genotypes were analyzed. Overall, 99 (83.2%) women had the same clinically relevant finding from both sampling methods. Twenty women had discordant hrHPV results (hrHPV detected in 10 self-samples vs 10 professionally collected samples; Cohen κ 0.66, 95% confidence interval 0.53-0.80). There was no significant difference between the two sampling methods for clinically significant infections (P>0.99) or extended genotyping (P=0.827).CONCLUSION: Postmenopausal women could be offered self-sampling devices to increase screening-program coverage while maintaining test quality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Cervical cancer
- HPV
- Postmenopausal women
- Professional sampling
- Screening
- Self-sample
Publication and Content Type
- ref (subject category)
- art (subject category)
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