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Serum Metabolites A...
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Dickens, Alex MountfortTurku Centre for Biotechnology, University of Turku, Turku, Finland
(author)
Serum Metabolites Associated with Computed TomographyFindings after Traumatic Brain Injury
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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Mary Ann Liebert,2018
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Numbers
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LIBRIS-ID:oai:DiVA.org:oru-67622
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67622URI
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https://doi.org/10.1089/neu.2017.5272DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:EU FP7 project TBIcare 270259 GE-NFL Head Health Challenge I Award 7620 Goverment's Special Financial Transfer tied to academic research in Health Sciences (Finland) Emil Aaltonen Foundation Finnish Brain Foundation National Institute for Health Research National Institute for Health Research and Biomedical Research Centre, Cambridge National Institute for Health Research Biomedical Research Center, Cambridge (Neuroscience Theme) National Institute for Health Research Biomedical Research Center, Cambridge (Brain Injury and Repair Theme) NIHR Biomedical Research Centre in Cambridge Academy of Medical Sciences/The Health Foundation Fellowship Academy of Medical Sciences/Health Foundation Senior Surgical Scientist Fellowship
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There is a need to rapidly detect patients with traumatic brain injury (TBI) who require head computed tomography (CT). Given the energy crisis in the brain following TBI, we hypothesized that serum metabolomics would be a useful tool for developing a set of biomarkers to determine the need for CT and to distinguish between different types of injuries observed. Logistic regression models using metabolite data from the discovery cohort (n=144, Turku, Finland) were used to distinguish between patients with traumatic intracranial findings and negative findings on head CT. The resultant models were then tested in the validation cohort (n=66, Cambridge, UK). The levels of glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 were also quantified in the serum from the same patients. Despite there being significant differences in the protein biomarkers in patients with TBI, the model that determined the need for a CT scan validated poorly (AUC=0.64: Cambridge patients). However, using a combination of six metabolites (two amino acids, three sugar derivatives and one ketoacid) it was possible to discriminate patients with intracranial abnormalities on CT and patients with a normal CT (AUC=0.77 in Turku patients and AUC=0.73 in Cambridge patients). Furthermore, a combination of three metabolites could distinguish between diffuse brain injuries and mass lesions (AUC=0.87 in Turku patients and AUC=0.68 in Cambridge patients). This study identifies a set of validated serum polar metabolites, which associate with the need for a CT scan. Additionally, serum metabolites can also predict the nature of the brain injury. These metabolite markers may prevent unnecessary CT scans, thus reducing the cost of diagnostics and radiation load.
Subject headings and genre
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Posti, Jussi P.Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland; Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, Turku, Finland
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Takala, Riikka Sk.Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, Turku, Finland
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Ala-Seppälä, Henna MariaDepartment of Neurology,University of Turku, Turku, Finland
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Mattila, IsmoSteno Diabetes Center AS, Gentofte, Denmark
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Coles, Jonathan ColesDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom of Great Britain and Northern Ireland
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Frantzén, JanekDivision of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland; Division of Clinical Neurosciences, Department of Neurosurgery,Turku University Hospital, Turku, Finland
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Hutchinson, Peter JohnDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom of Great Britain and Northern Ireland
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Katila, Ari J.Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, Turku, Finland
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Kyllönen, AnnaDepartment of Neurology, University of Turku, Turku, Finland
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Maanpää, Henna-RiikkaDivision of Clinical Neurosciences, Turku University Hospital, Turku, Finland
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Newcombe, VirginiaDivision of Anaesthesia, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom of Great Britain and Norther Ireland
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Outtrim, JoanneDivision of Anaesthesia, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom of Great Britain and Northern Ireland
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Tallus, JussiDivision of Anaesthesia, Addenbrooke's Hospital, Hills Road, University of Cambridge, Cambridge, United Kingdom of Great Britain and Northern Ireland
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Carpenter, KeriDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom of Great Britain and Northern Ireland
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Menon, DavidHead, Division of Anaesthesia, Addenbrooke's Hospital, Cambridge, United Kingdom of Great Britain and Northern Ireland
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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn
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Tenovuo, OlliDivision of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland
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Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku, Turku, Finland(Swepub:oru)moc
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Turku Centre for Biotechnology, University of Turku, Turku, FinlandDivision of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland; Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, Turku, Finland
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In:Journal of Neurotrauma: Mary Ann Liebert35:22, s. 2673-26830897-71511557-9042
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Dickens, Alex Mo ...
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Takala, Riikka S ...
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Frantzén, Janek
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Hutchinson, Pete ...
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Katila, Ari J.
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Outtrim, Joanne
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Tallus, Jussi
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Carpenter, Keri
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Menon, David
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Tenovuo, Olli
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