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Advancing the publi...
Advancing the public health applications of Chlamydia trachomatis serology
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- Woodhall, Sarah C. (author)
- Public Health England, London, UK; University of Bristol, Bristol, UK; University College London, London, UK
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- Gorwitz, Rachel J. (author)
- US Centers for Disease Control and Prevention, Atlanta GA, USA
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- Migchelsen, Stephanie J. (author)
- Public Health England, London, UK; London School of Hygiene & Tropical Medicine, London, UK
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- Gottlieb, Sami L. (author)
- World Health Organization, Geneva, Switzerland
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- Horner, Patrick J. (author)
- University of Bristol, Bristol, UK
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- Geisler, William M. (author)
- University of Alabama, Birmingham AL, USA
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- Winstanley, Catherine (author)
- University of Southampton, Southampton, UK
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- Hufnagel, Katrin (author)
- German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Waterboer, Tim (author)
- German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Martin, Diana L. (author)
- US Centers for Disease Control and Prevention, Atlanta GA, USA
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- Huston, Wilhelmina M. (author)
- University of Technology Sydney, Sydney NSW, Australia
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- Gaydos, Charlotte A. (author)
- Johns Hopkins University, Baltimore MD, USA
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- Deal, Carolyn (author)
- National Institute of Health, Bethesda MD, USA
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- Unemo, Magnus, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Örebro University Hospital, Örebro, Sweden
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- Dunbar, J. Kevin (author)
- Public Health England, London, UK; University of Bristol, Bristol, UK; University College London, London, UK
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- Bernstein, Kyle (author)
- US Centers for Disease Control and Prevention, Atlanta GA, USA
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- English.
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In: The Lancet - Infectious diseases. - : Elsevier. - 1473-3099 .- 1474-4457. ; 18:12, s. E399-E407
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Genital Chlamydia trachomatis infection is the most commonly diagnosed sexually transmitted infection. Trachoma is caused by ocular infection with C trachomatis and is the leading infectious cause of blindness worldwide. New serological assays for C trachomatis could facilitate improved understanding of C trachomatis epidemiology and prevention. C trachomatis serology offers a means of investigating the incidence of chlamydia infection and might be developed as a biomarker of scarring sequelae, such as pelvic inflammatory disease. Therefore, serological assays have potential as epidemiological tools to quantify unmet need, inform service planning, evaluate interventions including screening and treatment, and to assess new vaccine candidates. However, questions about the performance characteristics and interpretation of C trachomatis serological assays remain, which must be addressed to advance development within this field. In this Personal View, we explore the available information about C trachomatis serology and propose several priority actions. These actions involve development of target product profiles to guide assay selection and assessment across multiple applications and populations, establishment of a serum bank to facilitate assay development and evaluation, and development of technical and statistical methods for assay evaluation and analysis of serological findings. The field of C trachomatis serology will benefit from collaboration across the public health community to align technological developments with their potential applications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Woodhall, Sarah ...
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Gorwitz, Rachel ...
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Migchelsen, Step ...
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Gottlieb, Sami L ...
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Horner, Patrick ...
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Geisler, William ...
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Winstanley, Cath ...
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Hufnagel, Katrin
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Waterboer, Tim
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Martin, Diana L.
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Huston, Wilhelmi ...
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Gaydos, Charlott ...
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Deal, Carolyn
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Unemo, Magnus, 1 ...
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Dunbar, J. Kevin
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Bernstein, Kyle
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- MEDICAL AND HEALTH SCIENCES
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Örebro University