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Reference ranges an...
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Derakhshan, ArashAcademic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,rasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland
(author)
Reference ranges and determinants of thyroid function during early pregnancy : the SELMA study
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-07-02
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Oxford University Press,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-68366
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68366URI
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https://doi.org/10.1210/jc.2018-00890DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-161115URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-69473URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:Exchange in Endocrinology Expertise (3E) program of the European Union of Medical Specialists (UEMS), Section and Board of Endocrinology ZOnMW VIDI 016.176.331 Erasmus MC MRACE grant County Council of Värmland, Sweden
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Context: Establishing reference ranges as well as identifying and quantifying the determinants of thyroid function during pregnancy is important for proper clinical interpretation and optimizing research efforts. However, such data are sparse, specifically for (F)T3 measurements and most studies do not take into account thyroid antibodies or hCG.Objective: To determine reference ranges and to identify/quantify determinants of TSH, FT4, FT3, TT4 and TT3.Design, Setting and Participants: This study included 2,314 participants of the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study, a population-based prospective pregnancy cohort of mother-child pairs. Reference ranges were calculated by 2.5-97.5th percentiles after excluding TPOAb and/or TgAb positive women.Intervention: None.Main Outcome Measures: TSH, FT4, FT3, TT4 and TT3 in prenatal serum.Results: After exclusion of TPOAb positive women, reference range were: TSH: 0.11-3.48 mU/L, FT4: 11.6-19.4 pmol/L, FT3: 3.72-5.92 pg/mL, TT4: 82.4-166.2 pmol/L and TT3: 1.28-2.92 nmol/L. Additional exclusion of TgAb positive women did not change the reference ranges substantially. Exposure to tobacco smoke, as assessed by questionnaires and serum cotinine, was associated with lower TSH and higher FT3 and TT3. BMI and gestational age were the main determinants of TSH (only for BMI), FT4, FT3, TT4 and TT3.Conclusions: We show that the exclusion of TgAb positive women on top of excluding TPOAb positive women hardly affects clinical reference ranges. We identified various relevant clinical determinants of TSH, FT4, FT3, TT4 and TT3 which could reflect endocrine disrupting effects and/or effects on thyroid hormone transport or deiodination.
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Shu, HuanStockholms universitet,Institutionen för miljövetenskap och analytisk kemi(Swepub:su)hush5382
(author)
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Broeren, Maarten A. C.Laboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, Veldhoven, De Run, The Netherlands,Maxima Med Ctr, Lab Clin Chem & Haematol, NL-5504 DB Veldhoven, Netherlands
(author)
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de Poortere, Ralph A.Laboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, Veldhoven, De Run, The Netherlands,Maxima Med Ctr, Lab Clin Chem & Haematol, NL-5504 DB Veldhoven, Netherlands
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Wikström, Sverre,1978-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University(Swepub:oru)sewm
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Peeters, Robin P.Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,rasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland
(author)
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Demeneix, BarbaraLaboratoire d'Evolution des Régulations Endocriniennes, Muséum National d'Histoire Naturelle, Paris, France,Museum Natl Hist Nat, Lab Evolut Regulat Endocriniennes, Paris
(author)
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Bornehag, Carl-Gustaf,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn Sch Med Mt Sinai, New York, NY(Swepub:kau)caguborn
(author)
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Korevaar, Tim I. M.Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,Erasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherlands
(author)
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Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlandsrasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland
(creator_code:org_t)
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In:Journal of Clinical Endocrinology and Metabolism: Oxford University Press103:9, s. 3548-35560021-972X1945-7197
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