Hospital admission with pneumonia and subsequent persistent risk of chronic kidney disease: national cohort study

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Sundin, Per-Ola,1971-Clinical Epidemiology and Biostatistics (author)

Hospital admission with pneumonia and subsequent persistent risk of chronic kidney disease : national cohort study

Article/chapterEnglish2018

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DOVE Medical Press Ltd.2018
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LIBRIS-ID:oai:DiVA.org:oru-68653
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68653URI
https://doi.org/10.2147/CLEP.S169039DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:138950899URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agency:UK Economic and Social Research Council RES-596-28-0001 ES/JO19119/1
Background: Although acute onset kidney complications associated with severe infections including pneumonia are well characterized, little is known about possible subsequent delayed risk of chronic kidney disease (CKD).Patients and methods: Associations between hospital admission with pneumonia in adulthood and raised risks of subsequent CKD were evaluated in a cohort of all male residents in Sweden born from 1952 to 1956 (n=284,198) who attended mandatory military conscription examinations in late adolescence (n=264,951) and were followed up through 2009. CKD and pneumonia were identified using Swedish national registers, and their associations were evaluated using Cox regression. Excluding the first year, the subsequent period was divided into <= 5, > 5-<= 15, and > 15 years after hospital admission with pneumonia. Follow-up ended on the date of first incident diagnosis of kidney disease, death, emigration, or December 31, 2009, whichever occurred first.Results: During a median follow-up of 36.7 (interquartile range 35.3-37.9) years from late adolescence, 5,822 men had an inpatient pneumonia diagnosis without contemporaneous kidney disease. Among exposed men, 136 (2.3%) were later diagnosed with CKD compared with 2,749 (1.2%) of the unexposed. The adjusted hazard ratio for CKD in the first year after the first episode of pneumonia was 14.55 (95% confidence interval, 10.41-20.32), identifying early onset kidney complications and possibly pre-existing undiagnosed CKD. Starting follow-up 1 year after pneumonia to reduce the potential influence of surveillance bias and the risk of reverse causation, the adjusted hazard ratio for CKD in the first 5 years of follow-up was 5.20 (95% confidence interval, 3.91-6.93) and then attenuated with increasing time.Conclusion: Pneumonia among inpatients is associated with a persistently increased risk for subsequent CKD, with the highest risk during the years immediately after pneumonia. Health care professionals should be aware of this period of heightened risk to facilitate early diagnosis and secondary preventive interventions.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Pneumonia
kidney disease
end-stage renal disease
inflammation
cohort study

Added entries (persons, corporate bodies, meetings, titles ...)

Udumyan, Ruzan,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics(Swepub:oru)run (author)
Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics(Swepub:oru)kafl (author)
Montgomery, Scott,1961-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College, London, UK,Clinical Epidemiology and Biostatistics(Swepub:oru)smy (author)
Clinical Epidemiology and BiostatisticsInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:Clinical Epidemiology: DOVE Medical Press Ltd.10, s. 971-9791179-1349

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