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Incidence, prevalen...
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Eriksson, Carl,1981-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology
(author)
Incidence, prevalence and clinical outcome of anaemia in inflammatory bowel disease : a population-based cohort study
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-08-01
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Blackwell Science Ltd.2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-68681
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68681URI
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https://doi.org/10.1111/apt.14920DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138943511URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding agency:Swedish government's Agreement on Medical Training and Research
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BACKGROUND: The incidence and short-term outcome of anaemia in inflammatory bowel disease (IBD) are largely unknown.AIM: To determine the incidence, prevalence and clinical outcome of anaemia in terms of resolution of anaemia within 12 months. We also planned to assess risk factors for anaemia in IBD.METHODS: A random sample of 342 patients was obtained from the population-based IBD cohort of Örebro University Hospital, Sweden, consisting of 1405 patients diagnosed between 1963 and 2010. Haemoglobin measurements recorded from 1 January 2011 to 31 December 2013 were extracted from the Clinical Chemistry data system.RESULTS: In Crohn's disease, the incidence rate of anaemia was 19.3 (95% CI: 15.4-23.7) per 100 person-years and the prevalence was 28.7% (CI: 22.0-36.2), compared with 12.9 (CI: 9.8-16.5) and 16.5% (CI: 11.2-22.9) for ulcerative colitis. Crohn's disease was associated with an increased incidence (OR = 1.60; CI: 1.02-2.51) and prevalence of anaemia (OR = 2.04; CI: 1.20-3.46) compared to ulcerative colitis. Stricturing disease phenotype in Crohn's disease (HR = 2.59; CI: 1.00-6.79) and extensive disease in ulcerative colitis (HR = 2.40; CI: 1.10-5.36) were associated with an increased risk of anaemia. Despite a higher probability of receiving specific therapy within 3 months from the diagnosis of anaemia, Crohn's disease patients had a worse outcome in terms of resolution of anaemia within 12 months (56% vs 75%; P = 0.03).CONCLUSIONS: Anaemia is a common manifestation of IBD even beyond the first years after the diagnosis of IBD. Crohn's disease is associated with both an increased risk and a worse outcome.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Henriksson, IdaDepartment of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
(author)
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Brus, Ole,1982-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics(Swepub:oru)oebs
(author)
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Zhulina, Yaroslava,1973-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology(Swepub:oru)yza
(author)
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Nyhlin, Nils,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology(Swepub:oru)nnn
(author)
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Tysk, CurtDepartment of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
(author)
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Montgomery, Scott,1961-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK,Clinical Epidemiology and Biostatistics(Swepub:oru)smy
(author)
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Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology(Swepub:oru)jshn
(author)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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In:Alimentary Pharmacology and Therapeutics: Blackwell Science Ltd.48:6, s. 638-6450269-28131365-2036
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Eriksson, Carl, ...
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Brus, Ole, 1982-
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Tysk, Curt
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