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Assessment of Neutr...
Assessment of Neutrophil Chemotaxis Upon G-CSF Treatment of Healthy Stem Cell Donors and in Allogeneic Transplant Recipients
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- Thunström Salzer, Anna (author)
- Umeå universitet,Onkologi,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Niemiec, Maria Joanna, 1984- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Hosseinzadeh, Ava (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Stylianou, Marios, 1981- (author)
- Umeå universitet,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Clinical Microbiology, Laboratory of Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Åström, Fredrik (author)
- Umeå universitet,Onkologi
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- Röhm, Marc (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för klinisk mikrobiologi
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- Ahlm, Clas, 1956- (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för klinisk mikrobiologi
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- Wahlin, Anders (author)
- Umeå universitet,Onkologi
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- Ermert, David (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för klinisk mikrobiologi
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- Urban, Constantin F. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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(creator_code:org_t)
- 2018-09-11
- 2018
- English.
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In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 9
- Related links:
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https://www.frontier...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Neutrophils are crucial for the human innate immunity and constitute the majority of leukocytes in circulation. Thus, blood neutrophil counts serve as a measure for the immune system's functionality. Hematological patients often have low neutrophil counts due to disease or chemotherapy. To increase neutrophil counts and thereby preventing infections in high-risk patients, recombinant G-CSF is widely used as adjunct therapy to stimulate the maturation of neutrophils. In addition, G-CSF is utilized to recruit stem cells (SCs) into the peripheral blood of SC donors. Still, the actual functionality of neutrophils resulting from G-CSF treatment remains insufficiently understood. We tested the ex vivo functionality of neutrophils isolated from blood of G-CSF-treated healthy SC donors. We quantified chemotaxis, oxidative burst, and phagocytosis before and after treatment and detected significantly reduced chemotactic activity upon G-CSF treatment. Similarly, in vitro treatment of previously untreated neutrophils with G-CSF led to reduced chemotactic activity. In addition, we revealed that this effect persists in the allogeneic SC recipients up to 4 weeks after neutrophil engraftment. Our data indicates that neutrophil quantity, as a sole measure of immunocompetence in high-risk patients should be considered cautiously as neutrophil functionality might be affected by the primary treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- neutrophil
- granulocyte colony stimulating factor (G-CSF)
- allogeneic transplant
- chemotaxis
- hematopoietic stern cell donor
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Thunström Salzer ...
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Niemiec, Maria J ...
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Hosseinzadeh, Av ...
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Stylianou, Mario ...
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Åström, Fredrik
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Röhm, Marc
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Ahlm, Clas, 1956 ...
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Wahlin, Anders
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Ermert, David
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Urban, Constanti ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Frontiers in Imm ...
- By the university
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Örebro University
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Umeå University