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  • Tomlins, Scott A. (author)

The role of SPINK1 in ETS rearrangement-negative prostate cancers

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Amsterdam :Elsevier,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-7063
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7063URI
  • https://doi.org/10.1016/j.ccr.2008.04.016DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117139702URI
  • https://lup.lub.lu.se/record/1201451URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in urine, and observed that SPINK1 outlier expression is an independent predictor of biochemical recurrence after resection. We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rhodes, Daniel R. (author)
  • Yu, Jianjun (author)
  • Varambally, Sooryanarayana (author)
  • Mehra, Rohit (author)
  • Perner, Sven (author)
  • Demichelis, Francesca (author)
  • Helgeson, Beth E. (author)
  • Laxman, Bharathi (author)
  • Morris, David S. (author)
  • Cao, Qi (author)
  • Cao, Xuhong (author)
  • Andrén, OveÖrebro universitet,Hälsoakademin(Swepub:oru)oan (author)
  • Fall, KatjaKarolinska Institutet(Swepub:oru)kafl (author)
  • Johnson, Laura (author)
  • Wei, John T. (author)
  • Shah, Rajal B. (author)
  • Al-Ahmadie, Hikmat (author)
  • Eastham, James A. (author)
  • Eggener, Scott E (author)
  • Fine, Samson W. (author)
  • Hotakainen, Kristina (author)
  • Stenman, Ulf-Håkan (author)
  • Tsodikov, Alex (author)
  • Gerald, William L. (author)
  • Lilja, HansLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-hli (author)
  • Reuter, Victor E. (author)
  • Kantoff, Phillip W. (author)
  • Scardino, Peter T. (author)
  • Rubin, Mark A. (author)
  • Bjartell, AndersLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups(Swepub:lu)kir-abj (author)
  • Chinnaiyan, Arul M. (author)
  • Örebro universitetHälsoakademin (creator_code:org_t)

Related titles

  • In:Cancer CellAmsterdam : Elsevier13:6, s. 519-281535-61081878-3686

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