Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model

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Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model

Davidov, Eugene (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Clish, Clary B. (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Oresic, Matej, 1967- (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Meys, Michael (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Stochaj, Wayne (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Snell, Philip (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Lavine, Gary (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Londo, Thomas R. (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Adourian, Aram (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Zhang, Xiang (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Johnston, Mark (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Morel, Nicole (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Marple, Edward W. (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Plasterer, Thomas N. (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Neumann, Eric (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

Verheij, Elwin (author): TNO Pharma, Zeist, The Netherlands

Vogels, Jack T. W. E. (author): TNO Pharma, Zeist, The Netherlands

Havekes, Louis M. (author): TNO Prevention and Health, Gaubius Laboratorium, Leiden, The Netherlands; Departments of Cardiology and Internal Medicine and Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands

van der Greef, Jan (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA; TNO Pharma, Zeist, The Netherlands; Departments of Cardiology and Internal Medicine and Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands

Naylor, Stephen (author): 1Beyond Genomics, Inc., Waltham, Massachusetts, USA

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1Beyond Genomics, Inc, Waltham, Massachusetts, USA TNO Pharma, Zeist, The Netherlands (creator_code:org_t)

Mary Ann Liebert, 2004
2004
English.
In: Omics. - : Mary Ann Liebert. - 1536-2310 .- 1557-8100. ; 8:4, s. 267-288

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Multitiered quantitative analysis of biological systems is rapidly becoming the desired approach to study hierarchical functional interactions between proteins and metabolites. We describe here a novel systematic approach to analyze organisms with complex metabolic regulatory networks. By using precise analytical methods to measure biochemical constituents and their relative abundance in whole plasma of transgenic ApoE*3-Leiden mice and an isogenic wild-type control group, simultaneous snapshots of metabolic and protein states were obtained. Novel data processing and multivariate analysis tools such as Impurity Resolution Software (IMPRESS) and Windows-based linear fit program (WINLIN) were used to compare protein and metabolic profiles in parallel. Canonical correlations of the resulting data show quantitative relationships between heterogeneous components in the TG animals. These results, obtained solely from whole plasma analysis allowed us, in a rapid manner, to corroborate previous findings as well as find new events pertaining to dominant and peripheral events in lipoprotein metabolism of a genetically modified mammalian organism in relation to ApoE3, a key mediator of lipoprotein metabolism.

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Bioinformatics a ...

Articles in the publication: Omics

By the university: Örebro University

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Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model

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