Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: the GENOBIN study

Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism : the GENOBIN study

Schwab, Ursula (author): chool of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland; Kuopio University Hospital, Kuopio, Finland

Seppänen-Laakso, Tuulikki (author): VTT Technical Research Centre of Finland, Espoo, Finland

Yetukuri, Laxman (author): VTT Technical Research Centre of Finland, Espoo, Finland

Ågren, Jyrki (author): Department of Physiology, University of Kuopio, Kuopio, Finland

Kolehmainen, Marjukka (author): chool of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland

Laaksonen, David E. (author): Department of Physiology, University of Kuopio, Kuopio, Finland; Department of Medicine, Kuopio University Hospital, Kuopio, Finland

Ruskeepää, Anna-Liisa (author): VTT Technical Research Centre of Finland, Espoo, Finland

Gylling, Helena (author): chool of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland; Kuopio University Hospital, Kuopio, Finland

Uusitupa, Matti (author): chool of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland

Oresic, Matej, 1967- (author): VTT Technical Research Centre of Finland, Espoo, Finland

(creator_code:org_t)

Related links:: https://doi.org/10.1...; show more...; https://journals.plo...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

BACKGROUND: The effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.METHODOLOGY/PRINCIPAL FINDINGS: Plasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8+/-2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.CONCLUSIONS/SIGNIFICANCE: Diet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.TRIAL REGISTRATION: ClinicalTrials.gov NCT00621205.

By the author/editor: Schwab, Ursula; Seppänen-Laakso, ...; Yetukuri, Laxman; Ågren, Jyrki; Kolehmainen, Mar ...; Laaksonen, David ...; show more...; Ruskeepää, Anna- ...; Gylling, Helena; Uusitupa, Matti; Oresic, Matej, 1 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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