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Overexpression of v...
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
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- Karpanen, Terhi (author)
- Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland;
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- Bry, Maija (author)
- Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Ollila, Hanna M. (author)
- Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Seppänen-Laakso, Tuulikki (author)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Liimatta, Erkki (author)
- Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
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- Leskinen, Hanna (author)
- Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
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- Kivelä, Riikka (author)
- Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Helkamaa, Teemu (author)
- Institute of Biomedicine, Department of Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Merentie, Mari (author)
- A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Kuopio, Kuopio, Finland
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- Jeltsch, Michael (author)
- Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Paavonen, Karri (author)
- Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Andersson, Leif C. (author)
- Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
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- Mervaala, Eero (author)
- Institute of Biomedicine, Department of Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Hassinen, Ilmo E. (author)
- Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
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- Ylä-Herttuala, Seppo (author)
- A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Kuopio, Kuopio, Finland
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- Oresic, Matej, 1967- (author)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Alitalo, Kari (author)
- Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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(creator_code:org_t)
- American Heart Association, 2008
- 2008
- English.
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In: Circulation Research. - : American Heart Association. - 0009-7330 .- 1524-4571. ; 103:9, s. 1018-1026
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Vascular endothelial growth factor (VEGF)-B is poorly angiogenic but prominently expressed in metabolically highly active tissues, including the heart. We produced mice expressing a cardiac-specific VEGF-B transgene via the alpha-myosin heavy chain promoter. Surprisingly, the hearts of the VEGF-B transgenic mice showed concentric cardiac hypertrophy without significant changes in heart function. The cardiac hypertrophy was attributable to an increased size of the cardiomyocytes. Blood capillary size was increased, whereas the number of blood vessels per cell nucleus remained unchanged. Despite the cardiac hypertrophy, the transgenic mice had lower heart rate and blood pressure than their littermates, and they responded similarly to angiotensin II-induced hypertension, confirming that the hypertrophy does not compromise heart function. Interestingly, the isolated transgenic hearts had less cardiomyocyte damage after ischemia. Significantly increased ceramide and decreased triglyceride levels were found in the transgenic hearts. This was associated with structural changes and eventual lysis of mitochondria, resulting in accumulation of intracellular vacuoles in cardiomyocytes and increased death of the transgenic mice, apparently because of mitochondrial lipotoxicity in the heart. These results suggest that VEGF-B regulates lipid metabolism, an unexpected function for an angiogenic growth factor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Keyword
- VEGF-B
- cardiac hypertrophy
- cardiac metabolism
- fatty acids
- mitochondria
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Karpanen, Terhi
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Bry, Maija
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Ollila, Hanna M.
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Seppänen-Laakso, ...
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Liimatta, Erkki
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Leskinen, Hanna
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Kivelä, Riikka
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Helkamaa, Teemu
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Merentie, Mari
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Jeltsch, Michael
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Paavonen, Karri
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Andersson, Leif ...
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Mervaala, Eero
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Hassinen, Ilmo E ...
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Ylä-Herttuala, S ...
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Oresic, Matej, 1 ...
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Alitalo, Kari
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
- Articles in the publication
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Circulation Rese ...
- By the university
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Örebro University